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lymphoid cells

Allergic Airway Recall Responses Require IL-9 from Resident Memory CD4+ T Cells

[Science Immunology] Using a mouse model of chronic allergen exposure followed by an allergen-free rest period, scientists characterized a subpopulation of CD4+ T cells that secreted IL-9 as an obligate effector cytokine.

In Situ Antigen Modification-Based Target-Redirected Universal Chimeric Antigen Receptor T (TRUE CAR-T) Cell Therapy in Solid Tumors

[Journal of Hematology & Oncology] Investigator established a target-redirected universal CAR-T cell therapeutic modality, in which exogenous antigens were loaded onto fusogenic nanoparticles to achieve in situ modification of cell membrane in solid tumors, providing targets for subsequent CAR-T cell therapy.

Autologous, Lentivirus-Modified, T Rapa Cell “Micropharmacies” for Lysosomal Storage Disorders

[EMBO Molecular Medicine] Scientists demonstrated that ex vivo lentivirus-modified, rapamycin-conditioned CD4+ T cells could also act as next-generation cellular delivery vehicles—that is, “micropharmacies”—to disseminate corrective enzymes for multiple lysosomal storage disorders.

Characterization and Induction of Tissue-Resident Gamma Delta T Cells to Target Hepatocellular Carcinoma

[Nature Communications] Investigators showed that higher intratumoral frequencies of γδ T cells, which have potential for HLA-unrestricted tumor reactivity, associated with enhanced hepatocellular carcinoma patient survival.

CART Cell Therapy and the Tumor Microenvironment: Current Challenges and Opportunities

[Molecular Therapy Oncolytics] Scientists provide an updated review and future perspectives on features of the tumor microenvironment that represent barriers to CART cell therapy efficacy, including competition for metabolic fuels, physical barriers to infiltration, and immunosuppressive factors.

Cabozantinib Enhances Anti-PD1 Activity and Elicits a Neutrophil-Based Immune Response in Hepatocellular Carcinoma

[Clinical Cancer Research] Tumor and blood samples were analyzed by flow cytometry, immunohistochemistry, transcriptome and cytokine profiling. Cabozantinib-related effects were validated in a colorectal cancer PDX model.

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