lymphoid cells

[Science Advances] ECM proteins, collagen I, collagen III, and elastin, blocked natural killer (NK) cell cytotoxicity and promoted their chemokine/cytokine production. NK cell cytotoxicity against major histocompatibility complex class I (MHC-I)–deficient melanoma in the skin was markedly increased by blocking tumor collagen deposition.

[Seminars in Cancer Biology] Scientists summarize the roles of distinct immunogenic cell death mechanisms on antitumor immunity and recent advances of ferroptosis-, necroptosis- and pyroptosis-inducing agents, and present perspectives on these cell death mechanisms in immunotherapy of SCLC.

[Thoracic Cancer] Investigators outline the basic structure and generation characteristic of chimeric antigen receptor-modified T (CAR-T) cells and summarize the common tumor-associated antigens in clinical trials of CAR-T cell therapy for lung cancer.

[Iovance Biotherapeutics, Inc.] Iovance Biotherapeutics, Inc. announced that the US FDA has allowed an IND to proceed for its first genetically modified TIL therapy, IOV-4001, for the treatment of unresectable or metastatic melanoma and stage III or IV NSCLC.

[Cancer Science] Scientists investigated how tumor epithelial cells influenced tumor growth and immune responses of hepatocellular carcinoma focusing on CD8+ T-cell infiltration and exhaustion.

[Molecular Therapy-Nucleic Acids] Initial in silico analysis predicted exons that can be skipped with minimal loss of neurofibromin function, which was confirmed with in vitro assessments utilizing an neurofibromatosis type 1 (Nf1) cDNA-based functional screening system.