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lymphoid cells

PRMT5 in T Cells Drives Th17 Responses, Mixed Granulocytic Inflammation, and Severe Allergic Airway Inflammation

[Journal of Immunology] Scientists showed that PRMT5 drove allergic airway inflammation in a mouse model reproducing multiple aspects of human severe asthma.

PDS Biotech Announces Achievement of an Enrollment Objective in National Cancer Institute-Led Phase II Clinical Trial of PDS0101-Based Combination in Advanced HPV-Associated Cancers

[PDS Biotechnology Corporation] PDS Biotechnology Corporation announced that the National Cancer Institute (NCI) has achieved the intended enrollment objective of 30 patients in the checkpoint inhibitor refractory arm of the NCI-Led Phase II clinical trial evaluating PDS0101 in combination with two investigational immune-modulating agents in advanced HPV-associated cancers.

Increased CD4+ T Cell Count Is Associated with Lower Anal Human Papillomavirus Prevalence among HIV-Positive Male Cohort in Taizhou, China: A Cross-Sectional Study

[BMC Infectious Diseases] A survey was conducted in men from an HIV cohort in Taizhou, China between 2016 and 2019. A face-to-face questionnaire interview was administered, and an anal-canal swab was collected for HPV genotyping.

Helios Expressing Regulatory T Cells Are Correlated with Decreased IL-2 Producing CD8 T Cells and Antibody Diversity in Mozambican Individuals Living Chronically with HIV-1

[BMC Immunology] Investigators analyzed the profile of regulatory T cells and their correlation with the status of T cells activation, the expression of IL-2 and IFNγ, and the profile of HIV-1 specific antibodies response in Mozambican people living chronically with HIV-1.

Innate Lymphoid Cells and COVID-19 Severity in SARS-CoV-2 Infection

[eLife] An observational study found that the abundance of innate lymphoid cells decreased more than 7-fold over the human lifespan - T cell subsets decreased less than two-fold - and is lower in males than in females.

ACE2-Independent Infection of T Lymphocytes by SARS-CoV-2

[Signal Transduction and Targeted Therapy] Scientists confirmed that SARS-CoV-2 viral antigen could be detected in patient peripheral blood cells or postmortem lung T cells, and the infectious virus could also be detected from viral antigen-positive PBCs.

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