lymphoid cells

[Hepatology] Investigators applied selection strategies to enrich innate lymphoid cells (ILC) populations in hepatocellular carcinoma (HCC) samples to investigate the effects of B cells on the immune reaction of ICOS+ ILC2 cells.

[Cell Metabolism] Researchers summarize recent advances of how metabolic circuits combined with epigenetic changes dictate T cell fate decisions and shape their functional states.

[Cell Reports Medicine] The authors used blood transcriptomics, multiparameter flow cytometry, and T cell receptor sequencing spanning the time of incident non-severe infection in unvaccinated virus-naive individuals to identify rapid type 1 interferon (IFN) responses common to other acute respiratory viruses and cell proliferation responses that discriminate SARS-CoV-2 from other viruses.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators found that acute Listeria monocytogenes infection produced a phenotypically and functionally complex Treg response comprising two separate suppressor cell subpopulations, with an early Treg peak occurring at 24 hour post-infection and a later peak arising by day seven.

[Journal of Clinical Investigation] The authors reported that targeting of HIF-1α suppressed PD-L1 expression on tumor cells and tumor-infiltrated myeloid cells, but unexpectedly induced PD-L1 in normal tissues by an IFNγ–dependent mechanism.

[Cell Reports] The authors identified an interferon-γ-regulated subset of monocytes, CCR2+ monocytes, as a driver of lung damage during influenza A virus infection.