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lymphoid cells
Immune Regulation News
The Inhibitory Coreceptor CD22 Restores B Cell Signaling by Developmentally Regulating Cd45−/− Immunodeficient B Cells
[Science Signaling] In their investigation of how BCR signaling was restored in Cd45−/− cells, scientists found that the coreceptor CD22 switched from an inhibitory to a stimulatory function in these cells.
Immune Regulation News
Phosphorylation of Serine-893 in CARD11 Suppresses the Formation and Activity of the CARD11-BCL10-MALT1 Complex in T and B Cells
[Science Signaling] Researchers demonstrated that PKCθ/β-dependent CARD11 phosphorylation also suppressed CARD11 functions in T or B cells.
Immune Regulation News
Liver Environment–Imposed Constraints Diversify Movement Strategies of Liver-Localized CD8 T Cells
[Journal of Immunology] Investigators developed a protocol to generate stable numbers of liver-located CD8 T cells, and used intravital microscopy to record movement patterns of CD8 T cells in livers of live mice.
Immune Regulation News
Tumor-Educated Tregs Drive Organ-Specific Metastasis in Breast Cancer by Impairing NK Cells in the Lymph Node Niche
[Cell Reports] Scientists investigated the impact of mammary tumorigenesis on regulatory T cells in distant organs and how this affected multi-organ metastatic disease.
Neural Cell News
Landscape of Surfaceome and Endocytome in Human Glioma Is Divergent and Depends on Cellular Spatial Organization
[Proceedings of the National Academy of Sciences of the United States of America] The authors developed a platform integrated with a newly curated tumor surfaceome classifier that allowed profiling of primary 3D cultures and intact patient glioma tumors with preserved tissue architecture.
Hematopoiesis News
Intellia Therapeutics Announces First Patient Dosed in Phase I/IIa Clinical Trial of NTLA-5001 for the Treatment of Acute Myeloid Leukemia
[Intellia Therapeutics, Inc.] Intellia Therapeutics, Inc. announced that the first patient has been dosed with NTLA-5001, the company’s ex vivo CRISPR/Cas9 genome editing candidate for the treatment of AML.