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lymphoid cells

The Inhibitory Coreceptor CD22 Restores B Cell Signaling by Developmentally Regulating Cd45−/− Immunodeficient B Cells

[Science Signaling] In their investigation of how BCR signaling was restored in Cd45−/− cells, scientists found that the coreceptor CD22 switched from an inhibitory to a stimulatory function in these cells.

Phosphorylation of Serine-893 in CARD11 Suppresses the Formation and Activity of the CARD11-BCL10-MALT1 Complex in T and B Cells

[Science Signaling] Researchers demonstrated that PKCθ/β-dependent CARD11 phosphorylation also suppressed CARD11 functions in T or B cells.

Liver Environment–Imposed Constraints Diversify Movement Strategies of Liver-Localized CD8 T Cells

[Journal of Immunology] Investigators developed a protocol to generate stable numbers of liver-located CD8 T cells, and used intravital microscopy to record movement patterns of CD8 T cells in livers of live mice.

Tumor-Educated Tregs Drive Organ-Specific Metastasis in Breast Cancer by Impairing NK Cells in the Lymph Node Niche

[Cell Reports] Scientists investigated the impact of mammary tumorigenesis on regulatory T cells in distant organs and how this affected multi-organ metastatic disease.

Landscape of Surfaceome and Endocytome in Human Glioma Is Divergent and Depends on Cellular Spatial Organization

[Proceedings of the National Academy of Sciences of the United States of America] The authors developed a platform integrated with a newly curated tumor surfaceome classifier that allowed profiling of primary 3D cultures and intact patient glioma tumors with preserved tissue architecture.

Intellia Therapeutics Announces First Patient Dosed in Phase I/IIa Clinical Trial of NTLA-5001 for the Treatment of Acute Myeloid Leukemia

[Intellia Therapeutics, Inc.] Intellia Therapeutics, Inc. announced that the first patient has been dosed with NTLA-5001, the company’s ex vivo CRISPR/Cas9 genome editing candidate for the treatment of AML.

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