Tag results:
lymphoid cells
Immune Regulation News
MicroRNA-142 Guards against Autoimmunity by Controlling Treg Cell Homeostasis and Function
[PLoS Biology] Scientists reported that mice with Treg cell–specific ablation of miR-142 developed a fatal systemic autoimmune disorder due to a breakdown in peripheral T cell tolerance.
Mesenchymal Cell News
Engineered Delivery of Dental Stem Cell-Derived Extracellular Vesicles for Periodontal Tissue Regeneration
[Advanced Healthcare Materials] Investigators developed a delivery platform for small extracellular vesicles derived from gingival MSCs to treat periodontitis.
Extracellular Matrix News
Synergistic Checkpoint-Blockade and Radiotherapy-Radiodynamic Therapy via an Immunomodulatory Nanoscale Metal-Organic Framework
[Nature Biomedical Engineering] Researchers reported the design, synthesis and performance of a bismuth-based nanoscale metal-organic framework that modulated the immunological and mechanical properties of the tumor microenvironment for enhanced radiotherapy-radiodynamic therapy.
Hematopoiesis News
Targeting the NOTCH1-MYC-CD44 Axis in Leukemia-Initiating Cells in T-ALL
[Leukemia] Secondary transplantation from PDX and ΔPTEN models of T-cell acute lymphoblastic leukemia (T-ALL), confirmed delayed leukemia development and extended survival of mice engrafted with T-ALL from ARV-825 treated mice, providing functional confirmation of depletion of leukemia-initiating cells.
Cell Therapy News
A Novel TanCAR Targeting IL13Rα2 and EphA2 for Enhanced Glioblastoma Therapy
[Molecular Therapy-Oncolytics] To improve CAR-T therapy for glioblastoma, a new TanCAR, comprising the tandem arrangement of IL13 and EphA2 scFv, was generated and validated in vitro and in vivo.
Cell Therapy News
Feasibility Study of a Novel Preparation Strategy for Anti-CD7 CAR-T Cells with a Recombinant Anti-CD7 Blocking Antibody
[Molecular Therapy-Oncolytics] The authors reported a new strategy of blocking the CD7 antigen on the T cell surface with a recombinant anti-CD7 antibody to obtain a sufficient amount of CD7-targeting CAR-T cells for T cell acute lymphoblastic leukemia treatment.