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lymphoid cells

Rapid Manufacturing of Non-Activated Potent CAR T Cells

[Nature Biomedical Engineering] Scientists showed that functional CAR T cells could be generated within 24 hours from T cells derived from peripheral blood without the need for T cell activation or ex vivo expansion.

FDA Grants Orphan Drug Designation to Natural Killer Cell Therapy for GI Cancers

[Healio] The FDA granted orphan drug designation to CYNK-101, an investigational natural killer cell-based therapy for treatment of advanced HER2/neu-positive gastric or gastroesophageal junction adenocarcinoma.

Combined Tumor and Immune Signals from Genomes or Transcriptomes Predict Outcomes of Checkpoint Inhibition in Melanoma

[Cell Reports Medicine] The authors analyzed whole-exome and bulk RNA sequencing of tumors from new and published cohorts of 189 and 178 patients with melanoma receiving checkpoint blockade, respectively.

A FBXO7/EYA2-SCFFBXW7 Axis Promotes AXL-Mediated Maintenance of Mesenchymal and Immune Evasion Phenotypes of Cancer Cells

[Molecular Cell] Researchers identified FBXO7 as a maintenance regulator of mesenchymal and immune evasion phenotypes of cancer cells.

Hypoxia-Driven Immunosuppression by Treg and Type-2 Conventional Dendritic Cells in Hepatocellular Carcinoma

[Hepatology] Scientists analyzed the immune landscapes of hypoxia-low and -high tumor regions using cytometry by time-of-flight, immunohistochemistry and transcriptomic analyses.

Impaired TRPM3-Dependent Calcium Influx and Restoration Using Naltrexone in Natural Killer Cells of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients

[Journal of Translational Medicine] Live cell immunofluorescent imaging was used to measure TRPM3-dependent Ca2+ influx in NK cells isolated from ten myalgic encephalomyelitis/chronic fatigue syndrome patients and ten age- and sex-matched healthy controls following modulation with TRPM3-agonist, pregnenolone sulfate and TRPM3-antaognist, ononetin.

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