Tag results:
lymphoid cells
Cell Therapy News
Rapid Manufacturing of Non-Activated Potent CAR T Cells
[Nature Biomedical Engineering] Scientists showed that functional CAR T cells could be generated within 24 hours from T cells derived from peripheral blood without the need for T cell activation or ex vivo expansion.
Cell Therapy News
FDA Grants Orphan Drug Designation to Natural Killer Cell Therapy for GI Cancers
[Healio] The FDA granted orphan drug designation to CYNK-101, an investigational natural killer cell-based therapy for treatment of advanced HER2/neu-positive gastric or gastroesophageal junction adenocarcinoma.
Human Immunology News
Combined Tumor and Immune Signals from Genomes or Transcriptomes Predict Outcomes of Checkpoint Inhibition in Melanoma
[Cell Reports Medicine] The authors analyzed whole-exome and bulk RNA sequencing of tumors from new and published cohorts of 189 and 178 patients with melanoma receiving checkpoint blockade, respectively.
Human Immunology News
A FBXO7/EYA2-SCFFBXW7 Axis Promotes AXL-Mediated Maintenance of Mesenchymal and Immune Evasion Phenotypes of Cancer Cells
[Molecular Cell] Researchers identified FBXO7 as a maintenance regulator of mesenchymal and immune evasion phenotypes of cancer cells.
Human Immunology News
Hypoxia-Driven Immunosuppression by Treg and Type-2 Conventional Dendritic Cells in Hepatocellular Carcinoma
[Hepatology] Scientists analyzed the immune landscapes of hypoxia-low and -high tumor regions using cytometry by time-of-flight, immunohistochemistry and transcriptomic analyses.
Human Immunology News
Impaired TRPM3-Dependent Calcium Influx and Restoration Using Naltrexone in Natural Killer Cells of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients
[Journal of Translational Medicine] Live cell immunofluorescent imaging was used to measure TRPM3-dependent Ca2+ influx in NK cells isolated from ten myalgic encephalomyelitis/chronic fatigue syndrome patients and ten age- and sex-matched healthy controls following modulation with TRPM3-agonist, pregnenolone sulfate and TRPM3-antaognist, ononetin.