lymphoid cells

[Frontiers in Immunology] Using a human in vitro tri-culture system of macrophages with activated autologous T cells and BRAFV600E mutant melanoma cells, scientists showed that activated T cells and the synthetic triterpenoid the methyl CDDO-Me attenuated immune suppression.

[Journal of Immunology] The authors found that human mucosa-associated invariant T (MAIT)cells are hypersensitive to leukocidin ED-mediated lysis and lost on exposure to the toxin, leaving a T cell population devoid of MAIT cells.

[Cell Reports] Using Powassan virus lethal and sub-lethal challenge models, the authors showed that robust B and T cell responses were necessary for immune protection.

[iScience] Investigators evaluated the immune properties of the HLA-A2 restricted CD8+ T cell epitopes containing mutations from B.1.1.7.

[iScience] Researchers provided a detailed analysis of the B cell response to SARS-CoV-2 in unexposed individuals.

[Science Translational Medicine] The authors reported the correlates of durability of humoral and cellular immune responses in 20 rhesus macaques immunized with single-shot Ad26.COV2.S and the immunogenicity of a booster shot at eight to ten months following the initial immunization.