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lymphoid cells
Immunology of Infectious Disease News
CoVac501, a Self-Adjuvanting Peptide Vaccine Conjugated with TLR7 Agonists, against SARS-CoV-2 Induces Protective Immunity
[Cell Discovery] In non-human primates, CoVac501 elicited high and persistent titers of protective neutralizing antibodies against multiple receptor-binding domain mutations, SARS-CoV-2 original strain, and variants.
Immunology of Infectious Disease News
Immunosuppressive Features of the Microenvironment in Lymph Nodes Granulomas from Tuberculosis and HIV Co-Infected Patients
[American Journal of Pathology] Poorly formed necrotic tuberculosis (TB) granulomas containing a high expression of Mycobacterium tuberculosis antigens were elevated in TB/HIV co-infected lymph nodes, and inducible nitric oxide synthase as well as Arg-1 expression was significantly higher in TB/HIV co-infected compared to HIV-negative TB or control tissues.
Immunology of Infectious Disease News
Detection of the HIV-1 Accessory Proteins Nef and Vpu by Flow Cytometry Represents a New Tool to Study Their Functional Interplay within a Single...
[Journal of Virology] Researchers showed that the combined expression of Nef and Vpu predicted the susceptibility of HIV-1-infected primary CD4+ T cells to antibody-dependent cellular cytotoxicity by HIV+ plasma.
Immunology of Infectious Disease News
Preexisting Memory CD4 T Cells in Naïve Individuals Confer Robust Immunity upon Hepatitis B Vaccination
[eLife] Scientists used high-throughput sequencing of memory CD4 TCRβ repertoire and machine learning to showed that individuals with preexisting vaccine-reactive memory CD4 T cell clonotypes elicited earlier and higher antibody titers and mounted a more robust CD4 T cell response to hepatitis B vaccine.
Human Immunology News
Human Skin-Resident Host T Cells Can Persist Long Term after Allogeneic Stem Cell Transplantation and Maintain Recirculation Potential
[Science Immunology] Researchers identified and characterize skin-resident T cells in humans defined by their long-term in situ lodgment.
Hematopoiesis News
CDK12 Activates MYC to Repress miR-28-5p/EZH2 and Amplifies Tonic BCR Signaling to Promote the Development of Diffuse Large B Cell Lymphoma
[Cancer Gene Therapy] Cyclin-dependent kinase 12 (CDK12) activated MYC to repress miR-28-5p/EZH2 and amplified tonic BCR signaling to promote the development of diffuse large B cell lymphoma (DLBCL), which might provide potential therapeutic targets for future therapeutic intervention in DLBCL.