lymphoid cells

[Cell Reports Medicine] The authors demonstrated the feasibility of infusing multiple doses of ex vivo activated and expanded autologous NK cells in patients with multiple myeloma post-autologous stem cell transplantation.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers investigated a method to skew CAR transduction toward naive T cells without physical cell sorting.

[Nature Communications] To target GRP78, scientists generated T cell expressing a GRP78-specific peptide-based CAR, which showed evidence of minimal fratricide post activation/transduction and antigen-dependent T cell differentiation.

[Nature Immunology] Scientists found that CCR6+ type 3 innate lymphoid cells could trigger an increase in the number of T cells infiltrating a tumor.

[Kite] Kite announced the FDA approved an update to the prescribing information for Yescarta® to include use of prophylactic corticosteroids across all approved indications.

[Developmental Cell] Scientists reported that the adhesion molecule intercellular adhesion molecule 1 (ICAM-1) co-localized with programmed death ligand 1 (PD-L1) on the exosomes; both ICAM-1 and PD-L1 were upregulated by interferon-γ.