lymphoid cells

[Nature Communications] Scientists showed single-cell T cell receptor (TCR) coupled with RNA sequencing of CD3+ T cells from 13 patients, sampled before and after alemtuzumab treatments. Effector memory T cells and loss of TCR repertoire diversity were prevalent in T cell large granular lymphocyte leukemia.

[Nature Nanotechnology] Researchers described a genetically engineered cell membrane nanovesicle that integrated antigen self-presentation and immunosuppression reversal for cancer immunotherapy.

[Nature Communications] The authors showed that broadening the number of neoantigen-reactive CD8+ T cell populations between pre-treatment to three weeks post-treatment distinguished patients with controlled disease compared to patients with progressive disease in metastatic urothelial carcinoma treated with PD-L1-blockade.

[Nature Communications] Investigators comprehensively analyzed peripheral blood and/or synovial fluid samples from 20 patients with immune-related adverse events, including arthritis, and unmasked a prominent Th1-CD8+ T cell axis in both blood and inflamed joints.

[Cancer Research] The authors used carbon monoxide, a short-lived gaseous molecule, to test if engaging moderate endoplasmic reticulum stress conditions could improve mitochondrial and anti-tumor functions in T cells.

[Nature Reviews Endocrinology] The authors review the current understanding of the genetics of autoimmune Addison disease and its position in the wider field of autoimmune disorders and discuss the mechanisms that could underlie the effects on the adrenal cortex.