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lymphoid cells

Demethylase JMJD2D Induces PD-L1 Expression to Promote Colorectal Cancer Immune Escape by Enhancing IFNGR1-STAT3-IRF1 Signaling

[Oncogene] Scientists reported that both PD-L1 and JMJD2D were frequently overexpressed in human colorectal cancer specimens with a significant positive correlation.

Key Interactions in the Trimolecular Complex Consisting of the Rheumatoid Arthritis-Associated DRB1*04:01 Molecule, the Major Glycosylated Collagen II Peptide and the T Cell Receptor

[Annals of the Rheumatic Diseases] The crystal structures identified peptide binding to DRB1*04:01 and potential side chain exposure to T cells.

Adenosine Receptor A2a Blockade by Caffeine Increases IFN–Gamma Production in Th1 Cells from Patients with Rheumatoid Arthritis

[Scandinavian Journal of Rheumatology] Peripheral blood mononuclear cells were obtained from the peripheral blood of healthy individuals and patients with rheumatoid arthritis.

Flowcytometry in Reactive Lymph Node Aspirates: Evaluation of Distribution of Populations with Immunophenotypic Outliers

[Cytopathology] Flowcytometry of FNA/ scrape material from 30 cases of benign lymph nodes was evaluated to study the distribution of lymphoid populations and assess presence and percentages of immunophenotypic outliers.

MicroRNA-139 Expression Is Dispensable for the Generation of Influenza-Specific CD8+ T Cell Responses

[Journal of Immunology] Using miRNA microarray profiling, investigators characterized the expression profile of naive and in vivo generated murine effector antiviral CD8+ T cells.

Androgen Receptor Signaling Promotes Treg Suppressive Function during Allergic Airway Inflammation

[Journal of Clinical Investigation] Using androgen receptor (AR) deficient and Foxp3 fate-mapping mice, researchers determined that AR signaling increased Treg suppression during Alternaria extract challenge by stabilizing Foxp3+ Tregs and limiting the number of ST2+ ex-Tregs and IL-13+ Th2 and ex-Tregs.

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