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lymphoid cells

Fewer LAG-3+ T Cells in Relapsing-Remitting Multiple Sclerosis and Type 1 Diabetes

[Journal of Immunology] The authors observed significantly fewer LAG-3+ CD4 and CD8 T cells from subjects with relapsing-remitting multiple sclerosis and type 1 diabetes.

Long Noncoding RNA HOTAIRM1 Promotes Immunosuppression in Sepsis by Inducing T Cell Exhaustion

[Journal of Immunology] Using a mouse model of sepsis, scientists found that the long noncoding RNA HOXA transcript antisense RNA myeloid-specific 1 (HOTAIRM1) was highly expressed in mice during the late phase of sepsis.

The Role of Indoleamine 2,3-Dioxygenase in Allergic Disorders

[Molecular Biology Reports] A considerable number of studies suggest that the role of indoleamine 2,3 dioxygenase in T helper 2 cell regulation may be different from that of T helper 1 immune responses.

T Cells: Friends and Foes in NASH Pathogenesis and Hepatocarcinogenesis

[Hepatology] Scientists review the specific functions of several T cell populations involved in NAFLD and NAFLD-driven HCC.

Sana Biotechnology Obtains Exclusive License from National Institutes of Health for CD22 CAR Construct

[Sana Biotechnology, Inc.] Sana Biotechnology, Inc. announced that the company entered into an agreement with the National Cancer Institution, an institute of the National Institutes of Health, for worldwide exclusive commercial rights to the NIH’s CD22 CAR with a fully-human binder for use in certain in vivo gene therapy and ex vivo allogeneic CAR T applications for B cell malignancies.

Targeting Prooxidant MnSOD Effect Inhibits Triple-Negative Breast Cancer (TNBC) Progression and M2 Macrophage Functions under the Oncogenic Stress

[Cell Death & Disease] Knockdown of MnSOD inhibited TNBC cell invasion, breast cancer stem cells, mitochondrial reactive oxygen species, and interleukin-6 excretion promoted by multiple copies in T cell malignancy-1.

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