lymphoid cells

[Rafael Pharmaceuticals, Inc. (Globe Newswire, Inc.)] Rafael Pharmaceuticals, Inc. announced the completion of the first cohort of dose escalation with no DLT in the APOLLO 613 Phase I/II clinical trial of devimistat in combination with hydroxychloroquine in patients with relapsed clear cell sarcoma.

[Science Immunology] Researchers developed a tumor-conditional interleukin-12 (pro-IL-12), which masked IL-12 with selective extracellular receptor–binding domains of the IL-12 receptor while preferentially and persistently activating tumor-infiltrating lymphocytes after being unmasked by matrix metalloproteinases expressed by tumors.

[Cellular and Molecular Life Sciences] Researchers investigated the molecular mechanisms that determined intercellular adhesion receptor (ICAM)-1 localization into apical membrane domains of polarized hepatic epithelial cells, and their effect on lymphocyte-hepatic epithelial cell interaction.

[Journal of Nanobiotechnology] Scientists presented a 3D hanging spheroid plate, which facilitated the formation of spheroids and the separation of unbound and dead cells from spheroids during cytotoxicity assays.

[Nature Communications] Investigators developed a B cell-activating factor (BAFF) ligand-based CAR and generated BAFF CAR-T cells using a non-viral gene delivery method.

[Cellular & Molecular Immunology] The in vivo recovery of cytomegalovirus (CMV)-specific immunity after CMV-cytotoxic T lymphocytes (CTL) infusion was comparable in two groups. A detailed analysis of the source of recovered CMV-CTLs showed the proliferation and expansion of graft-derived endogenous CMV-CTLs in both groups.