Excellent Outcome for Pediatric Patients With High-Risk Hodgkin Lymphoma Treated With Brentuximab Vedotin and Risk-Adapted Residual Node Radiation

Brentuximab vedotin, an effective anti-CD30 antibody-drug conjugate approved for use in adults with classical Hodgkin lymphoma (HL), was introduced in this frontline trial to reduce prescribed radiation in children and adolescents with classical HL.
[Journal of Clinical Oncology]
Metzger, M. L., Link, M. P., Billett, A. L., Flerlage, J., Lucas, J. T., Mandrell, B. N., Ehrhardt, M. J., Bhakta, N., Yock, T. I., Friedmann, A. M., de Alarcon, P., Luna-Fineman, S., Larsen, E., Kaste, S. C., Shulkin, B., Lu, Z., Li, C., Hiniker, S. M., Donaldson, S. S., … Krasin, M. J. (2021). Excellent Outcome for Pediatric Patients With High-Risk Hodgkin Lymphoma Treated With Brentuximab Vedotin and Risk-Adapted Residual Node Radiation. Journal of Clinical Oncology, JCO.20.03286. https://doi.org/10.1200/JCO.20.03286 Cite
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CAR-T Cell Therapy: Current Limitations and Potential Strategies

Scientists discuss recent innovations in CAR-T cell engineering to improve clinical efficacy in both hematological malignancy and solid tumors and strategies to overcome limitations of CAR-T cell therapy in both hematological malignancy and solid tumors.
[Blood Cancer Journal]
Sterner, R. C., & Sterner, R. M. (2021). CAR-T cell therapy: current limitations and potential strategies. Blood Cancer Journal, 11(4), 1–11. https://doi.org/10.1038/s41408-021-00459-7 Cite
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Diffuse Large B-Cell Lymphoma: New Targets and Novel Therapies

Three CAR-T cell products are currently approved by the FDA, with others in clinical trials. Additional agents in development include bispecific antibodies and antibody drug conjugates.
[Blood Cancer Journal]
Cheson, B. D., Nowakowski, G., & Salles, G. (2021). Diffuse large B-cell lymphoma: new targets and novel therapies. Blood Cancer Journal, 11(4), 1–10. https://doi.org/10.1038/s41408-021-00456-w Cite
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BCL3 Couples Cancer Stem Cell Enrichment with Pancreatic Cancer Molecular Subtypes

Scientists demonstrated that Bcl3 impacted pancreatic carcinogenesis by restraining cancer stem cell expansion and by curtailing an aggressive and metastatic tumor burden in pancreatic ductal adenocarcinoma across species.
[Gastroenterology]
Ai, J., Wörmann, S. M., Görgülü, K., Vallespinos, M., Zagorac, S., Alcala, S., Wu, N., Kabacaoglu, D., Berninger, A., Navarro, D., Kaya-Aksoy, E., Ruess, D. A., Ciecielski, K. J., Kowalska, M., Demir, E. I., Ceyhan, G. O., Heid, I., Braren, R., Riemann, M., … Algül, H. (2021). BCL3 couples cancer stem cell enrichment with pancreatic cancer molecular subtypes. Gastroenterology, 0(0). https://doi.org/10.1053/j.gastro.2021.03.051 Cite
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Roche Receives Positive CHMP Opinion for Tecentriq as a First-Line Monotherapy Treatment for People with a Type of Metastatic Non-Small Cell Lung Cancer

Roche announced that the European Medicines Agency’s Committee for Medicinal Products for Human Use has recommended the approval of Tecentriq® as a first-line treatment for adults with metastatic non-small cell lung cancer whose tumors have high PD-L1 expression, with no epidermal growth factor receptor or anaplastic lymphoma kinase genomic tumor aberrations.
[Roche]
Press Release
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A Cross-Talk between CAR T Cell Subsets and the Tumor Microenvironment Is Essential for Sustained Cytotoxic Activity

Researchers report an essential cross-talk between CAR T cell subsets and the TME for tumor control in an immunocompetent mouse B cell lymphoma model of anti-CD19 CAR T cell therapy.
[Science Immunology]
Boulch, M., Cazaux, M., Loe-Mie, Y., Thibaut, R., Corre, B., Lemaître, F., Grandjean, C. L., Garcia, Z., & Bousso, P. (2021). A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity. Science Immunology, 6(57). https://doi.org/10.1126/sciimmunol.abd4344 Cite
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CircRNA RSF1 Regulated Ox-LDL Induced Vascular Endothelial Cells Proliferation, Apoptosis and Inflammation through Modulating miR-135b-5p/HDAC1 Axis in Atherosclerosis

ox-LDL inhibited circRSF1 and histone deacetylase 1 (HDAC1) expression while upregulated miR-135b-5p expression in HUVECs.
[Biological Research]
Zhang, X., Lu, J., Zhang, Q., Luo, Q., & Liu, B. (2021). CircRNA RSF1 regulated ox-LDL induced vascular endothelial cells proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in atherosclerosis. Biological Research, 54(1), 11. https://doi.org/10.1186/s40659-021-00335-5 Cite
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Quantification of T Cell Clonality in Human T Cell Leukaemia Virus Type-1 Carriers Can Detect the Development of Adult T Cell Leukaemia Early

Scientists showed that adult T cell leukemia/lymphoma (ATL) could be detected early in HTLV-1-carriers through quantification of T-cell receptor (TCR)Vβ subunit diversity on T-cells infected with HTLV-1 using an ‘oligoclonality index’.
[Blood Cancer Journal]
Wolf, S. N., Haddow, J., Greiller, C., Taylor, G. P., Cook, L. B. M., & Rowan, A. G. (2021). Quantification of T cell clonality in human T cell leukaemia virus type-1 carriers can detect the development of adult T cell leukaemia early. Blood Cancer Journal, 11(3), 1–11. https://doi.org/10.1038/s41408-021-00458-8 Cite
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A Novel lncRNA TCLlnc1 Promotes Peripheral T Cell Lymphoma Progression through Acting as a Modular Scaffold of HNRNPD and YBX1 Complexes

In this research, a novel lncRNA was identified overexpressed in the main subtypes of peripheral T cell lymphoma, and designated as T cell lymphoma-associated lncRNA1.
[Cell Death & Disease]
Zhao, P., Ji, M.-M., Fang, Y., Li, X., Yi, H.-M., Yan, Z.-X., Cheng, S., Xu, P.-P., Janin, A., Wang, C.-F., Wang, L., & Zhao, W.-L. (2021). A novel lncRNA TCLlnc1 promotes peripheral T cell lymphoma progression through acting as a modular scaffold of HNRNPD and YBX1 complexes. Cell Death & Disease, 12(4), 1–14. https://doi.org/10.1038/s41419-021-03594-y Cite
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Trispecific CD19-CD20-CD22–Targeting duoCAR-T Cells Eliminate Antigen-Heterogeneous B Cell Tumors in Preclinical Models

Researchers engineered trispecific duoCAR-T cells with lentiviral vectors encoding two CAR open reading frames that target CD19, CD20, and CD22.
[Science Translational Medicine]
Schneider, D., Xiong, Y., Wu, D., Hu, P., Alabanza, L., Steimle, B., Mahmud, H., Anthony-Gonda, K., Krueger, W., Zhu, Z., Dimitrov, D. S., Orentas, R. J., & Dropulić, B. (2021). Trispecific CD19-CD20-CD22–targeting duoCAR-T cells eliminate antigen-heterogeneous B cell tumors in preclinical models. Science Translational Medicine, 13(586). https://doi.org/10.1126/scitranslmed.abc6401 Cite
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Single-Cell Analysis by Mass Cytometry Reveals Metabolic States of Early-Activated CD8+ T Cells during the Primary Immune Response

To understand the metabolic state of rare, early-activated T cells, scientists adapted mass cytometry to quantify metabolic regulators at single-cell resolution in parallel with cell signaling, proliferation, and effector function.
[Immunity]
Levine, L. S., Hiam-Galvez, K. J., Marquez, D. M., Tenvooren, I., Madden, M. Z., Contreras, D. C., Dahunsi, D. O., Irish, J. M., Oluwole, O. O., Rathmell, J. C., & Spitzer, M. H. (2021). Single-cell analysis by mass cytometry reveals metabolic states of early-activated CD8+ T cells during the primary immune response. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2021.02.018 Cite
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