lymphoma

[Cancer Science] The authors investigated the anti-adult T cell leukemia/lymphoma effects of a novel oral HSP90 inhibitor TAS-116 and the mechanisms involved in ex vivo and in vivo preclinical models.

[Laboratory Investigation] Scientists explored putative mechanisms of microRNA-155-5p involvement in childhood acute lymphoblastic leukemia via interactions with casitas B-lineage lymphoma (CBL), interferon regulatory factor 4 (IRF4), and cyclin-dependent kinase 6 (CDK6).

[Science Translational Medicine] Researchers found that the cytokine oncostatin M was highly up-regulated in psoriasis, atopic dermatitis, and cutaneous T cell lymphoma, diseases associated with chronic itch.

[Haematologica] The authors retrospectively reviewed the characteristics and outcomes of adult patients with relapsed/refractory large B-cell lymphoma treated with Standard of care axicabtagene ciloleucel or tisagenlecleucel .

[Haematologica] The authors showed that, unlike normal B cells, diffuse large B cell lymphoma (DLBCL) cells express abundant levels of transducin b-like protein 1 and its overexpression correlates with poor clinical outcome regardless of DLBCL molecular subtype.

[Hematological Oncology] Scientists address treatment duration and sequence considerations and discuss current targeted treatment dilemmas of chronic lymphocytic leukemia, where they review B cell lymphoma 2 inhibitors and Bruton’s tyrosine kinase in a fixed duration and continuous treatment manner.