lymphoma

[Cell Reports] Investigators mapped the cleavage site to Asn654-Leu655 and demonstrated that cleavage inhibition of wild-type anaplastic lymphoma kinase significantly impeded neuroblastoma cell migration with subsequent prolongation of survival in mouse models.

[Cancer Science] Scientists showed that the bromodomain-containing protein 4 (BRD4) inhibitor JQ1 promoted the apoptosis of B16 melanoma cells by altering mitochondrial dynamics, thereby inducing mitochondrial dysfunction and increasing oxidative stress.

[Blood Advances] Untreated older acute myeloid leukemia (AML) patients were randomized to cytarabine and daunorubicin followed by cytarabine consolidation with or without G3139. Addition of G3139 to chemotherapy failed to improve outcomes of older AML patients.

[Blood] To identify and interrogate malignant clones in matched skin and blood from leukemic MF and SS patients, we combine T cell receptor clonotyping, with quantification of gene expression and cell surface markers at the single cell level.

[Blood] The authors revealed a frequent activation of RelB in a large cohort of diffuse large B-cell lymphoma patients and cell lines, independently of their ABC or GCB subtypes.

[Scientific Reports] Scientists screened a total of 521 tumor specimens from Chinese patients with lung cancer for anaplastic lymphoma receptor tyrosine kinase fusion by immunohistochemistry and confirmed by fluorescence in situ hybridization.