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lymphoma

Inhibition of MCL1 Induces Apoptosis in Anaplastic Large Cell Lymphoma and in Primary Effusion Lymphoma

[Scientific Reports] To find additional hematologic entities with ectopic expression of BCL2 family members, investigators performed expression screening of cell lines applying the LL-100 panel.

IMV Announces First Patient Dosed in the VITALIZE Phase IIB Clinical Study Evaluating its Lead Compound, MVP-S, in Combination with KEYTRUDA® (pembrolizumab) in Patients...

[IMV Inc.] IMV, Inc., a clinical-stage company developing a portfolio of immune-educating therapies based on its novel DPX platform to treat solid and hematologic cancers, announced a first patient dosed in the VITALIZE Phase IIB clinical trial.

HUTCHMED Receives Breakthrough Therapy Designation in China for HMPL-523 for Treatment of Primary Immune Thrombocytopenia

[HUTCHMED Limited (Globe Newswire, Inc.)] HUTCHMED Limited announced that the Center for Drug Evaluation of China’s National Medical Products Administration has granted Breakthrough Therapy Designation to HMPL-523, a novel, investigational spleen tyrosine kinase inhibitor, for the treatment of chronic adult primary immune thrombocytopenia patients who have received at least one prior therapy.

A Subset of Follicular Helper-Like MAIT Cells Can Provide B Cell Help and Support Antibody Production in the Mucosa

[Science Immunology] Scientists described a population of CXCR5+ T follicular helper–like mucosal-associated invariant T (MAIT) cells that have the capacity to provide B cell help within mucosal lymphoid organs.

Hypoxia-Inducible Factor 1α Induces Osteo/Odontoblast Differentiation of Human Dental Pulp Stem Cells via Wnt/β-Catenin Transcriptional Cofactor BCL9

[Scientific Reports] The authors examined the role of B-cell CLL/lymphoma 9 (BCL9), which is downstream of hypoxia-inducible factor 1α and a Wnt/β-catenin transcriptional cofactor, in the osteo/odontoblastic differentiation of human dental pulp stem cells under hypoxic conditions.

Flowcytometry in Reactive Lymph Node Aspirates: Evaluation of Distribution of Populations with Immunophenotypic Outliers

[Cytopathology] Flowcytometry of FNA/ scrape material from 30 cases of benign lymph nodes was evaluated to study the distribution of lymphoid populations and assess presence and percentages of immunophenotypic outliers.

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