M-CSF Supports Medullary Erythropoiesis and Erythroid Iron Demand Following Burn Injury through Its Activity on Homeostatic Iron Recycling

The authors found M-CSF secretion was increased in burn patients and a murine model of post burn ACI, so they neutralized M-CSF in ACI mice to determine if erythropoiesis was improved.
[Scientific Reports]
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CRISPR/Cas9-Mediated Gene Disruption of Endogenous Co-Receptors Confers Broad Resistance to HIV-1 in Human Primary Cells and Humanized Mice

In a humanized mouse model under HIV-1 challenge, CXCR4-disrupted CD4+ T cells were enriched in the peripheral blood and spleen, indicating survival advantage due to resistance to viral infection.
[Molecular Therapy-Methods & Clinical Development]
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Exosome-Mediated Delivery of Transforming Growth Factor-β Receptor 1 Kinase Inhibitors and Toll-Like Receptor 7/8 Agonists for Combination Therapy of Tumors

Combination therapy with the transforming growth factor-β receptor I kinase inhibitor SD-208 and a toll-like receptor-7/8 agonist resiquimod was examined along with serum-derived exosomes as versatile carriers and may serve as a promising strategy to treat melanoma and prostate cancer.
[Acta Biomaterialia]
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A Muscle Cell-Macrophage Axis Involving Matrix Metalloproteinase 14 Facilitates Extracellular Matrix Remodeling with Mechanical Loading

Using single-cell RNA-seq, scientists identified macrophages as a source of matrix metalloproteinase 14 in muscle following a hypertrophic exercise stimulus in mice.
[FASEB Journal]
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Immuno-Engineered Nanodecoys for the Multi-Target Anti-Inflammatory Treatment of Autoimmune Diseases

IFN-γ treatment induced remarkable PD-L1 expression on PD-L1-expressing macrophage membrane (PRM), thereby allowing PRM nanodecoys to bind mPD-1 on CD4+ T cell surfaces or neutralize free sPD-1, which reconstructed the PD-1/PD-L1 inhibitory axis to suppress CD4+ T cell activation and restore immune tolerance.
[Advanced Materials]
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ISM1 Protects Lung Homeostasis via Cell-Surface GRP78-Mediated Alveolar Macrophage Apoptosis

Researchers reported that absence of isthmin 1 (ISM1) in mice led to increase in both alveolar macrophages number and functional heterogeneity, with enduring lung inflammation, progressive emphysema, and significant lung function decline, phenotypes similar to human obstructive pulmonary disease.
[Proceedings of the National Academy of Sciences of the United States of America]
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Sox9/CXCL5 Axis Facilitates Tumor Cell Growth and Invasion in Hepatocellular Carcinoma

Investigators observed that the increase of Sox9 significantly promoted hepatocellular carcinoma cell growth and invasion in cell cultures, whereas knockdown of Sox9 showed the opposite effects, suggesting that Sox9 may regulate the proliferation and invasion of hepatoma cells in an autocrine manner.
[FEBS Journal]
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FOXP3 Activated-LINC01232 Accelerates the Stemness of Non-Small Cell Lung Carcinoma by Activating TGF-β Signaling Pathway and Recruiting IGF2BP2 to Stabilize TGFBR1

Flow cytometry and sphere formation assays indicated that LINC01232 significantly promoted non-small cell lung carcinoma cell stemness.
[Experimental Cell Research]
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Chemokine CCL18 Promotes Phagocytosis Through Its Receptor CCR8 Rather than PITPNM3 in Human Microglial Cells

Investigators showed that CCL18 did not change the expression of the inflammatory factors, interleukin (IL)-1β, IL-6, tumor necrosis factor alpha, or inducible nitric oxide synthase, but significantly induced expression of the macrophage markers, MRC-1 and ARG-1 M2, in a human microglial clone 3 cell line
[Journal of Interferon and Cytokine Research]
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Therapeutic Potential of Colchicine in Cardiovascular Medicine: A Pharmacological Review

The authors summarize the current clinical trials with proven curative effect of colchicine in treating cardiovascular diseases.
[Acta Pharmacologica Sinica]
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miR-204–Containing Exosomes Ameliorate GVHD-Associated Dry Eye Disease

Investigators reported that exosomes from MSCs administered as eye drops notably alleviated graft-versus-host disease-associated dry eye disease by suppressing inflammation and improving epithelial recovery in mice and humans.
[Science Advances]
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