macrophages

[Cell Discovery] To delineate the cellular and molecular changes during the development of thoracic aortic aneurysm and dissection (TAAD), scientists performed single-cell RNA sequencing of thoracic aortic cells from β-aminopropionitrile-induced TAAD mouse models at three time points that spanned from the early to the advanced stages of the disease.

[British Journal of Cancer] KDM6A promoted the transcription of SPARCL1 by demethylating histone H3 lysine trimethylation and consequently led to the inactivation of p65. SPARCL1 affected the metastasis of gastrointestinal stromal tumor cells in a mesenchymal-epithelial transition- and matrix-metalloproteinase-dependent manner.

[Developmental Cell] Researchers observed unexpectedly high levels of hepatocyte heterogeneity in the developing liver and the progressive construction of the zonated metabolic functions from pericentral to periportal hepatocytes, which was orchestrated with the development of sinusoid endothelial, stellate, and Kupffer cells.

[Cell Death & Disease] Scientists assessed the composition and production mechanisms, as well as the clinical significance and biological properties, of soluble CD74 in melanoma.

[Nature Communications] In wild type endothelial cells Lkb1 phosphorylates polypyrimidine tract binding protein 1 at threonine 138, which regulated stem cell factor pre-mRNA splicing.

[Circulation] Investigators utilized mouse models of reperfused myocardial infarction, angiotensin II and phenylephrine infusion, and diphtheria toxin cardiomyocyte ablation to investigate C-C chemokine ligand 17.