macrophages

[Annual Review of Medicine] Scientists propose and demonstrate that myelogenous leukemia has a preleukemic phase. In the premalignant phase, normal HSCs gradually accumulate mutations leading to HSC clonal expansion, resulting in the emergence of leukemic stem cells.

[Cell Metabolism] By screening the expression and functional characterization of olfactory receptors in pancreatic islets, investigators identified Olfr109 as the receptor that detects insulin peptides.

[Environmental Science and Pollution Research] The authors examined the viability of BEAS-2B and mRNA/protein expression profile of oxidative stress and inflammatory response-related transcription factors Nrf2, NF-kB, and according inflammatory indicators such as IL-1, IL-6, and IL-8, with a view to evaluating the effects of different interaction models of PM2.5 on epithelial cell damage in vitro.

[Akeso, Inc. (PR Newswire, Inc.)] Akeso, Inc. announced that Ligufalimab and Ivonescimab have obtained approval from the Center for Drug Evaluation of the National Medical Products Administration of the People's Republic of China to initiate a Phase II clinical trial with chemotherapy as first-line therapy for unresectable locally advanced or metastatic triple negative breast cancer.

[iScience] Scientists generated a doxycycline inducible MHC-I and II antigen expressing HCC cell line which allowed them to investigate tumor antigen specific T cell response in two non-alcoholic fatty liver disease (NAFLD) mouse models.

[Pharmacological Research] Scientists screened and verified the differential expression of circ_0001142 in breast cancer tissues and cell lines through bioinformatics and qRT-PCR.