Improved Diabetic Wound Healing by Bovine Lactoferricin Is Associated with Relevant Changes in the Skin Immune Response and Microbiota

The wound healing potential of bovine lactoferricin was investigated using in vitro, ex vivo, and in vivo models. Cell migration and proliferation were tested on keratinocytes and on porcine ears.
[Molecular Therapy-Methods & Clinical Development]
Mouritzen, M. V., Petkovic, M., Qvist, K., Poulsen, S. S., Alarico, S., Leal, E. C., Dalgaard, L. T., Empadinhas, N., Carvalho, E., & Jenssen, H. (2021). Improved diabetic wound healing by bovine lactoferricin is associated with relevant changes in the skin immune response and microbiota. Molecular Therapy - Methods & Clinical Development, 0(0). https://doi.org/10.1016/j.omtm.2021.02.008 Cite
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CHBP Induces Stronger Immunosuppressive CD127+ M-MDSC via Erythropoietin Receptor

Researchers investigated the effects on myeloid-derived suppressor cells (MDSC) differentiation and immunosuppressive function via cyclic helix B peptide (CHBP) induction.
[Cell Death & Disease]
Li, J., Tu, G., Zhang, W., Zhang, Y., Zhang, X., Qiu, Y., Wang, J., Sun, T., Zhu, T., Yang, C., & Rong, R. (2021). CHBP induces stronger immunosuppressive CD127 + M-MDSC via erythropoietin receptor. Cell Death & Disease, 12(2), 1–12. https://doi.org/10.1038/s41419-021-03448-7 Cite
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Macrophages Support the Aggressive Mechanical Phenotype of Circulating Tumor Cells in Prostate Cancer

Investigators recapitulated the tumor cells – macrophages interactions in cell culture using prostate cancer cell lines.
[Biophysical Journal]
Osmulski, P. A., Cunsolo, A., Qian, Y., Chen, M., Lin, C.-L., Hung, C.-N., Mahalingam, D., Kirma, N., Chen, C.-L., Taverna, J., Liss, M., Thompson, I. M., Huang, T. H., & Gaczynska, M. (2021). Macrophages Support the Aggressive Mechanical Phenotype of Circulating Tumor Cells in Prostate Cancer. Biophysical Journal, 120(3), 64a–65a. https://doi.org/10.1016/j.bpj.2020.11.619 Cite
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Medical Progress: Stem Cells as a New Therapeutic Strategy for COVID-19

Researchers discuss the latest discoveries in molecular biology, a platform model of pluripotent stem cells in the SARS-CoV-2 study on 3D animal models and nanoconjugates based on stem cells.
[Stem Cell Research]
Musial, C., & Gorska-Ponikowska, M. (2021). Medical progress: Stem cells as a new therapeutic strategy for COVID-19. Stem Cell Research, 102239. https://doi.org/10.1016/j.scr.2021.102239 Cite
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Sulfated Polysaccharide Directs Therapeutic Angiogenesis via Endogenous VEGF Secretion of Macrophages

In a macrophage-inhibited mouse model, sulfated chitosan efficiently helped to recover the endogenous levels of VEGF and the number of CD31hiEmcnhi vessels in ischemia.
[Science Advances]
Yu, Y., Dai, K., Gao, Z., Tang, W., Shen, T., Yuan, Y., Wang, J., & Liu, C. (2021). Sulfated polysaccharide directs therapeutic angiogenesis via endogenous VEGF secretion of macrophages. Science Advances, 7(7), eabd8217. https://doi.org/10.1126/sciadv.abd8217 Cite
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Withaferin A Alleviates Fulminant Hepatitis by Targeting Macrophage and NLRP3

Researchers evaluated the hepatoprotective role and mechanism of Withaferin A in D-galactosamine/lipopolysaccharide-induced fulminant hepatitis.
[Cell Death & Disease]
Xia, Y., Wang, P., Yan, N., Gonzalez, F. J., & Yan, T. (2021). Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3. Cell Death & Disease, 12(2), 1–14. https://doi.org/10.1038/s41419-020-03243-w Cite
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The IKZF1-IRF4/IRF5 Axis Controls Polarization of Myeloma-Associated Macrophages

Scientists observed that myeloma-associated macrophages derived from patients treated with the immunomodulatory drug lenalidomide skewed phenotypically and functionally toward an M1 phenotype.
[Cancer Immunology Research]
Mougiakakos, D., Bach, C., Böttcher, M., Beier, F., Röhner, L., Stoll, A., Rehli, M., Gebhard, C., Lischer, C., Eberhardt, M., Vera, J., Büttner-Herold, M., Bitterer, K., Balzer, H., Leffler, M., Jitschin, S., Hundemer, M., Awwad, M. H. S., Busch, M., … Bruns, H. (2021). The IKZF1-IRF4/IRF5 Axis Controls Polarization of Myeloma-Associated Macrophages. Cancer Immunology Research. https://doi.org/10.1158/2326-6066.CIR-20-0555 Cite
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Augmented Antibody-Based Anti-cancer Therapeutics Boost Neutrophil Cytotoxicity

Researchers combined the agonistic activity of IgG monoclonal antibodies and IgA Fc receptor targeting in a therapeutic bispecific antibody format.
[Journal of Clinical Investigation]
Heemskerk, N., Gruijs, M., Temming, A. R., Heineke, M. H., Gout, D. Y., Hellingman, T., Tuk, C. W., Winter, P. J., Lissenberg-Thunnissen, S., Bentlage, A. E. H., Donatis, M. D., Bögels, M., Rösner, T., Valerius, T., Bakema, J. E., Vidarsson, G., & Egmond, M. van. (2021). Augmented antibody-based anti-cancer therapeutics boost neutrophil cytotoxicity. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI134680 Cite
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Determinants, Mechanisms, and Outcomes of Myeloid Cell Diversity in Cancers

Researchers discuss the multifaceted roles of tumorā€associated macrophages and neutrophils, focusing on factors that subvert tissue immune homeostasis and offer therapeutic opportunities for tumor microenvironment reprogramming.
[Immunological Reviews]
Caronni, N., Montaldo, E., Mezzanzanica, L., Cilenti, F., Genua, M., & Ostuni, R. (n.d.). Determinants, mechanisms, and outcomes of myeloid cell diversity in cancer. Immunological Reviews, n/a(n/a). https://doi.org/https://doi.org/10.1111/imr.12944 Cite
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Macrophages Provide a Transient Muscle Stem Cell Niche via NAMPT Secretion

Researchers used muscle injury models in zebrafish to systematically capture the interactions between satellite cells and the innate immune system after injury, in real time, throughout the repair process.
[Nature]
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Tumor-Derived Exosomal MicroRNA-106b-5p Activates the Interaction between EMT-Cancer Cells and M2-Subtype TAMs to Facilitate Colorectal Cancer Metastasis

Scientists found that epithelial-mesenchymal transition (EMT)-colorectal cancer cells promoted the M2-like polarization of macrophages by directly transferring exosomes to macrophages, leading to a significant increase of miR-106b level in macrophages.
[Molecular Therapy]
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