Tag results:
macrophages
Immune Regulation News
Disruption of USP9X in Macrophages Promotes Foam Cell Formation and Atherosclerosis
[Journal of Clinical Investigation] Using a loss-of-function lipid accumulation screening, scientists identified ubiquitin-specific peptidase 9 X-linked (USP9X) as a factor that suppressed lipid uptake in macrophages.
Mammary Cell News
Modification of BRCA1-Associated Breast Cancer Risk by HMMR Overexpression
[Nature Communications] Researchers depicted an interplay of molecular, cellular, and tissue microenvironment alterations that increased BRCA1-associated breast cancer risk.
Pulmonary Cell News
Lipidomic Profiling of Bronchoalveolar Lavage Fluid Extracellular Vesicles Indicates Their Involvement in Lipopolysaccharide-Induced Acute Lung Injury
[Journal of innate Immunity] Extracellular vesicles released during acute lung injury originated from alveolar epithelial cells, macrophages, and neutrophils and carry a diverse array of lipid mediators derived from ω-3 and ω-6 polyunsaturated fatty acids.
Human Immunology News
Cathelicidin Mediates an Anti-Inflammatory Role of Active Vitamin D (Calcitriol) During M. paratuberculosis Infection
[Frontiers in Cellular and infection Microbiology] Scientists examined the role of vitamin D deficiency in the regulation of cathelicidin antimicrobial peptide in Crohn’s disease (CD)-like macrophages, including those infected with Mycobacterium avium subsp. paratuberculosis isolated from CD patients.
Immunology of Infectious Disease News
NK Cells and Monocytes Modulate Primary HTLV-1 Infection
[PLoS Pathogens] The authors investigated the impact of monocytes, NK cells, and CD8+ T cells in primary HTLV-1 infection by depleting cell subsets and exposing macaques to either HTLV-1 wild type or to the HTLV-1p12KO mutant.
Pulmonary Cell News
27-Hydroxycholesterol Linked High Cholesterol Diet to Lung Adenocarcinoma Metastasis
[Oncogene] The authors evidenced that cholesterol promoted cell proliferation and invasion of lung adenocarcinoma (LAC) in vitro as well as LAC metastasis in vivo.