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macrophages

Disruption of USP9X in Macrophages Promotes Foam Cell Formation and Atherosclerosis

[Journal of Clinical Investigation] Using a loss-of-function lipid accumulation screening, scientists identified ubiquitin-specific peptidase 9 X-linked (USP9X) as a factor that suppressed lipid uptake in macrophages.

Modification of BRCA1-Associated Breast Cancer Risk by HMMR Overexpression

[Nature Communications] Researchers depicted an interplay of molecular, cellular, and tissue microenvironment alterations that increased BRCA1-associated breast cancer risk.

Lipidomic Profiling of Bronchoalveolar Lavage Fluid Extracellular Vesicles Indicates Their Involvement in Lipopolysaccharide-Induced Acute Lung Injury

[Journal of innate Immunity] Extracellular vesicles released during acute lung injury originated from alveolar epithelial cells, macrophages, and neutrophils and carry a diverse array of lipid mediators derived from ω-3 and ω-6 polyunsaturated fatty acids.

Cathelicidin Mediates an Anti-Inflammatory Role of Active Vitamin D (Calcitriol) During M. paratuberculosis Infection

[Frontiers in Cellular and infection Microbiology] Scientists examined the role of vitamin D deficiency in the regulation of cathelicidin antimicrobial peptide in Crohn’s disease (CD)-like macrophages, including those infected with Mycobacterium avium subsp. paratuberculosis isolated from CD patients.

NK Cells and Monocytes Modulate Primary HTLV-1 Infection

[PLoS Pathogens] The authors investigated the impact of monocytes, NK cells, and CD8+ T cells in primary HTLV-1 infection by depleting cell subsets and exposing macaques to either HTLV-1 wild type or to the HTLV-1p12KO mutant.

27-Hydroxycholesterol Linked High Cholesterol Diet to Lung Adenocarcinoma Metastasis

[Oncogene] The authors evidenced that cholesterol promoted cell proliferation and invasion of lung adenocarcinoma (LAC) in vitro as well as LAC metastasis in vivo.

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