macrophages

[Journal of Immunology] Scientists described an immunomodulatory role for an aromatic keto acid, indole-3-pyruvate (I3P). They demonstrated that I3P inhibited the production of PGs in activated macrophages.

[Current Opinion in Immunology] The authors discuss how newly described decidual innate lymphoid cells and maternal placenta-associated macrophage subsets may be involved in anti-pathogen defense.

[Molecular Therapy-Oncolytics] Scientists found that oncolytic adenovirus conferred an effective ability to reduce ascites development and prolong overall survival.

[Science Advances] Investigators reported that interleukin-4 –induced M0 → M2 macrophage polarization was accompanied by interchangeable glucose- or lactate-dependent tricarboxylic acid cycle metabolism that directly drove histone acetylation, M2 gene transcription, and functional immune suppression.

[Laboratory Investigation] Researchers demonstrated that lipopolysaccharide promoted c-Jun N-terminal kinase signaling pathway activation and endogenous tumor necrosis factor-α secretion in pulmonary macrophages.

[Nature Reviews Cardiology] Investigators highlight efforts to develop imaging techniques and to therapeutically manipulate macrophages in atherosclerotic plaques with the use of rationally designed nanoparticles, and review the latest progress in nanoparticle-based imaging modalities that can specifically target macrophages.