Macrophage Metabolic Reprogramming Presents a Therapeutic Target in Lupus Nephritis

Investigators found that human and mouse macrophages underwent a switch to glycolysis in response to IgG immune complex stimulation, mirroring macrophage metabolic changes in inflamed tissue in vivo. This metabolic reprogramming was required to generate a number of proinflammatory mediators, including IL-1β, and was dependent on mTOR and hypoxia-inducible factor-1α.
[Proceedings of the National Academy of Sciences of the United States of America]
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Distribution of Nerve Fibers and Nerve-Immune Cell Association in Mouse Spleen Revealed by Immunofluorescent Staining

Scientists demonstrated extensive nerve fibers in all splenic compartments including the splenic nodules, periarteriolar lymphoid sheath, marginal zones, trabeculae, and red pulp; close associations of nerve fibers with blood vessels; and close associations of nerve fibers with various subsets of dendritic cells, macrophages, and lymphocytes
[Scientific Reports]
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Vagus Nerve Stimulation Even after Injury Ameliorates Cisplatin-Induced Nephropathy via Reducing Macrophage Infiltration

To explore the role of the spleen and splenic macrophages, key players in the cholinergic anti-inflammatory pathway, splenectomy, and adoptive transfer of macrophages treated with the selective α7 nicotinic acetylcholine receptor agonist GTS-21 were conducted.
[Scientific Reports]
Uni, R., Inoue, T., Nakamura, Y., Fukaya, D., Hasegawa, S., Wu, C.-H., … Inagi, R. (2020). Vagus nerve stimulation even after injury ameliorates cisplatin-induced nephropathy via reducing macrophage infiltration. Scientific Reports, 10(1), 9472. https://doi.org/10.1038/s41598-020-66295-0 Cite
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Activation of GPR35 Protects against Cerebral Ischemia by Recruiting Monocyte-Derived Macrophages

The flowcytometric analysis shows the expression of G protein coupled receptor 35 (GPR35) on the infiltrating monocytes/macrophages and neutrophils in the ischemic brain.
[Scientific Reports]
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Determinants of Resident Tissue Macrophage Identity and Function

The authors review recent findings within this context and discuss the technological advances that are revolutionizing the study of macrophage biology.
[Immunity]
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Neutrophils Preferentially Phagocytose Elongated Particles—An Opportunity for Selective Targeting in Acute Inflammatory Diseases

Scientists investigated the phagocytosis of rod-shaped polymeric particles by human neutrophils relative to other leukocytes. In contrast to macrophages and other mononuclear phagocytes, neutrophils were found to exhibit increased internalization of rods in ex vivo and in vivo experimentation.
[Science Advances]
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Tumor-Associated Macrophages in Classical Hodgkin Lymphoma: Hormetic Relationship to Outcome

MYC+ cells accounted for 21% and 18% of CD68+ and CD163+ cells, respectively. Numbers of MYC macrophages were significantly higher in EBV+ cases while no differences were observed for MYC+ macrophages between EBV+ and EBV cases.
[Scientific Reports]
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Myeloid ALX/FPR2 Regulates Vascularization Following Tissue Injury

Mechanistically, RNA sequencing revealed that resolvin D1 induced a transcriptional program in macrophages characteristic of a pro-revascularization phenotype. Vascularization of ischemic skeletal muscle, as well as cutaneous wounds, was impaired in mice with myeloid-specific deficiency of Alx/Fpr2, and this was associated with altered expression of pro-revascularization genes in skeletal muscle and macrophages isolated from skeletal muscle.
[Proceedings of the National Academy of Sciences of the United States of America]
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Essential Contribution of Macrophage Tie2 Signaling in a Murine Model of Laser-Induced Choroidal Neovascularization

Scientists observed that Tie2-expressing macrophages prevented apoptosis of b.End3 cells, but promoted their migration, proliferation and tube formation via VEGF, extracellular signal-regulated kinase and v-akt murine thymoma viral oncogene-dependent signaling pathways.
[Scientific Reports]
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