macrophages

[Nature Immunology] Scientists investigated the single-cell phenotypes associated with antimicrobial responses in human leprosy granulomas by applying single-cell and spatial sequencing to leprosy biopsy specimens.

[Cell Reports] Delivery of regulatory macrophages (Mregs) completely abolished the priming of cognate CD8 cells and strongly reduced delayed-type hypersensitivity reactions. Mreg-mediated T cell suppression requires cell-cell contact-regulated nitric oxide production.

[Genome Biology] By analyzing inducible gene-disrupted mice, researchers showed that DNA demethylation during primary T cell differentiation occured mainly through passive replication-dependent dilution of all three oxi-mCs, with only a negligible contribution from DNA glycosylase.

[JCI Insight] Investigators showed that macrophages contributed significantly to the loss of β-cells and the subsequent development of hyperglycemia. Depletion or inhibition of 12-LOX in this model resulted in reduced macrophage infiltration into islets and the preservation of β-cell mass.

[Cell Death & Disease] Scientists showed that monocyte/macrophage CD11B mRNA levels were increased significantly in livers of biliary atresia patients and positively correlated with the progression of liver inflammation and fibrosis.

[Nature Communications] Investigators found that the interferon gamma-regulated transcriptional program in macrophages is controlled by ADP-ribosylation of STAT1α, a post-translational modification resulting in the site-specific covalent attachment of ADP-ribose moieties.