Tumor-Initiating Cells Establish an IL-33–TGF-β Niche Signaling Loop to Promote Cancer Progression

The authors showed, using a mouse model of squamous cell carcinoma, that tumor-initiating cells play a crucial role in creating a niche microenvironment that is required for tumor progression and drug resistance.
[Science]
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Allogeneic Adipose‐Derived Stem Cells Promote Ischemic Muscle Repair by Inducing M2 Macrophage Polarization via the HIF ‐1α/IL ‐10 Pathway

The transplantation of adipose‐derived mesenchymal stem cells (ASCs) into ischemic limbs induced increased blood flow reperfusion and limb salvage rate, whereas the depletion of tissue macrophages or transplanting HIF‐1α‐silenced ASCs inhibited the therapeutic effect.
[Stem Cells]
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Intra-Articular Xenogeneic Mesenchymal Stem Cell-Based Therapy Increases CD4+CD25+ Cells in Synovial Fluid

The authors aimed to identify the lymphocytic response to a xenogeneic human umbilical cord-derived mesenchymal stem cell-based cell therapy.
[Veterinary Immunology and Immunopathology]
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Xenogeneic Mesenchymal Stem Cell Transplantation for Mandibular Defect Regeneration

To examine donor cell survival and host immune reaction, pig bone marrow‐derived mesenchymal stem cells were labeled with CM‐DiI, loaded onto gelatin sponge, and transplanted into 5‐mm mandibular defects of immunocompetent and T cell‐deficient athymic rats.
[Xenotransplantation]
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Light-Triggered Switching of Liposome Surface Charge Directs Delivery of Membrane Impermeable Payloads In Vivo

Prior to light activation, intravenously administered liposomes, composed of just two lipid reagents, freely circulated and successfully evaded innate immune cells present in the fish.
[Nature Communications]
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Genetically Modified Macrophages Accomplish Targeted Gene Delivery to the Inflamed Brain in Transgenic Parkin Q311X(A) Mice: Importance of Administration Routes

Researchers report fundamental changes in biodistribution and brain bioavailability of macrophage-based formulations upon different routes of administration: intravenous, intraperitoneal, or intrathecal injections.
[Scientific Reports]
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Combination of Apolipoprotein-a-I/Apolipoprotein-a-I Binding Protein and Anti-VEGF Treatment Overcomes Anti-VEGF Resistance in Choroidal Neovascularization in Mice

Scientists explored the unique property of the apolipoprotein A-I binding protein that enhanced cholesterol efflux from endothelial cells and macrophages to thereby limited angiogenesis and inflammation to tackle anti-VEGF resistance in choroidal neovascularization.
[Communications Biology]
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Inhibition of CCL2 by Bindarit Alleviates Diabetes-Associated Periodontitis by Suppressing Inflammatory Monocyte Infiltration and Altering Macrophage Properties

Scientists found that persistently elevated CCL2 levels in combination with proinflammatory monocyte infiltration of periodontal tissues were closely related to diabetes-associated periodontitis.
[Cellular & Molecular Immunology]
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Early Modulation of Macrophage ROS-PPARγ-NF-κB Signaling by Sonodynamic Therapy Attenuates Neointimal Hyperplasia in Rabbits

5-aminolevulinic acid-mediated sonodynamic therapy inhibited neointima formation without affecting re-endothelialization, increased blood perfusion, decreased the content of macrophages, proliferating smooth muscle cells and collagen but increased elastin by day 28.
[Scientific Reports]
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Ornithine-A Urea Cycle Metabolite Enhances Autophagy and Controls Mycobacterium tuberculosis Infection

A metabolomics comparison of Mycobacterium tuberculosis (Mtb)-infected macrophages indicated that ornithine and imidazole were two top-scoring metabolites in Mtb-infected Kupffer cells and that acetylcholine was the top-scoring in Mtb-infected mouse alveolar macrophages..
[Nature Communications]
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Macrophage Exosomes Resolve Atherosclerosis by Regulating Hematopoiesis and Inflammation via MicroRNA Cargo

Scientists showed that exosomes produced by naive bone marrow-derived macrophages (BMDM) contained anti-inflammatory microRNA-99a/146b/378a that were further increased in exosomes produced by BMDM polarized with IL-4.
[Cell Reports]
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