Tag results:

macrophages

MYC-Mediated Early Glycolysis Negatively Regulates Proinflammatory Responses by Controlling IRF4 in Inflammatory Macrophages

[Cell Reports] Metabolic and molecular analyses reveal that MYC, but not hypoxia inducible factor 1, was involved in enhancing early glycolytic flux during inflammatory macrophage polarization.

Macrophage Depletion Induces Edema through Release of Matrix-Degrading Proteases and Proteoglycan Deposition

[Science Translational Medicine] Extended antibody treatment of mice caused marked body weight gain, an indicator of enhanced body fluid retention. This was associated with an increase of ECM–remodeling metalloproteinases (MMPs), namely MMP2 and MMP3, and enhanced deposition of hyaluronan and proteoglycans, leading to skin thickening.

Necroptosis Protects against Exacerbation of Acute Pancreatitis

[Cell Death & Disease] Researchers found that Ripk3−/− mice had significantly more severe pancreatic edema and inflammation associated with macrophage and neutrophil infiltration than control mice.

TAM Kinase Signaling Is Indispensable for Proper Skeletal Muscle Regeneration in Mice

[Cell Death & Disease] The authors investigated the involvement of TAM receptor kinases Mer and Axl in the muscle regeneration process by studying the muscle repair following cardiotoxin-induced injury in Mer−/− mice.In vitro inhibition of TAM kinase signaling in C2C12 myoblasts resulted in decreased viability and in impaired myotube growth.

Blocking Siglec-10hi Tumor-Associated Macrophages Improves Anti-Tumor Immunity and Enhances Immunotherapy for Hepatocellular Carcinoma

[Experimental Hematology & Oncology] Immunohistochemistry and flow cytometry were performed to detect the characteristics of sialic acid-binding immunoglobulin-like lectin 10high (Siglec-10hi) tumor-associated macrophages and explore their impact on the tumor microenvironment of hepatocellular carcinoma.

Tim-4+ Cavity-Resident Macrophages Impair Anti-Tumor CD8+ T Cell Immunity

[Cancer Cell] The authors showed that metastatic disease in the pleural and peritoneal cavities is associated with poor clinical outcomes after immune checkpoint blockade therapy.

Popular