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macrophages

SARS-CoV-2 Envelope Protein Causes Acute Respiratory Distress Syndrome (ARDS)-Like Pathological Damages and Constitutes an Antiviral Target

[Cell Research] Researchers showed that the SARS-CoV-2 envelope protein alone is able to cause acute respiratory distress syndrome-like damages in vitro and in vivo.

Targeting the SHP2 Phosphatase Promotes Vascular Damage and Inhibition of Tumor Growth

[EMBO Molecular Medicine] The authors reported that SHP2 was an essential promoter of endothelial cell survival and growth in the remodeling tumor vasculature.

Synergistic Immunotherapy of Glioblastoma by Dual Targeting of IL-6 and CD40

[Nature Communications] Researchers identified a Stat3/HIF-1α-mediated axis, through which IL-6 executed an anti-tumor role to induce CD40 expression in Mϕs.

Integrating Longitudinal Clinical Laboratory Tests with Targeted Proteomic and Transcriptomic Analyses Reveal the Landscape of Host Responses in COVID-19

[Cell Discovery] Comparison of the transcriptomes of the bronchoalveolar microenvironment and peripheral blood indicates alveolar macrophages, alveolar epithelial cells, and monocytes in lungs as the potential main sources of elevated cytokines mediating systemic immune responses and organ damages.

In Vitro Expansion of Fetal Liver Hematopoietic Stem Cells

[Scientific Reports] Scientists explored the expansion of fetal liver hematopoietic stem cells under in vitro conditions. They isolated mononuclear cells from fetal liver and hematopoietic stem cells were identified and analyzed by cell surface marker CD34.

Blockade of the Co-Inhibitory Molecule PD-1 Unleashes ILC2-Dependent Antitumor Immunity in Melanoma

[Nature Immunology] Scientists found that high group 2 innate lymphoid cells (ILC2) infiltration in human melanoma was associated with a good clinical prognosis. ILC2s were critical producers of the cytokine granulocyte-macrophage colony-stimulating factor, which coordinated the recruitment and activation of eosinophils to enhance antitumor responses.

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