malaria

[Ebiomedicine] The authors undertook a comprehensive study of T-follicular helper cells, along with B cells and antibody induction in children and adults with malaria.

[Vaccine] Investigators identified immunodominant portions of four malaria vaccine candidate antigens using peripheral blood mononuclear cells from adults with life-long exposure to malaria parasites.

[International Journal For Parasitology] Scientists describe clonal expansion in the variable region of immunoglobulin heavy chains of antigen-specific single B cells collected from humans immunized with Pfs230D1-EPA or Pfs25-EPA conjugate vaccines formulated in Alhydrogel®.

[Science Translational Medicine] The authors investigated the impact of repeated P. falciparum infections on human γδ T cells in the context of natural infection in Malian children and adults, as well as serial controlled human malaria infection of US adults, some of whom became clinically immune to malaria.

[Med] The authors demonstrated that the delayed fractional dose maintained monocyte phagocytosis and NK activation mediated by NANP6-specific antibodies, key correlates of protection for the RTS,S/AS01 doses regimen.

[BMC Medicine] Parasitemia was measured using qPCR; immunogenicity was determined using standard assays. Parasites were rescued into culture for in vitro analyses.