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malaria

Plasmodium Sporozoite Phospholipid Scramblase Interacts with Mammalian Carbamoyl-Phosphate Synthetase 1 to Infect Hepatocytes

[Nature Communications] Investigators screened a phage display library for peptides that structurally mimicked a sporozoite ligand for hepatocyte recognition.

Atovaquone-HSA Nano-Drugs Enhance the Efficacy of PD-1 Blockade Immunotherapy by Alleviating Hypoxic Tumor Microenvironment

[Journal of Nanobiotechnology] The authors exploited atovaquone/albumin nanoparticles to improve bioavailability and tumor targeting of atovaquone, enhancing the efficacy of anti-PD-1 therapy by normalizing tumor hypoxia.

Immunoprofiles Associated with Controlled Human Malaria Infection and Naturally Acquired Immunity Identify a Shared IgA Pre-erythrocytic Immunoproteome

[npj Vaccines] Scientists described immunoproteome differences in naïve versus exposed individuals and reported pre-erythrocytic proteins recognized by the immune system.

Hemozoin-Mediated Inflammasome Activation Limits Long-Lived Anti-Malarial Immunity

[Cell Reports] Using multiple Plasmodium species, genetically modified parasites, and combinations of host genetic and pharmacologic approaches, researchers found that the deposition of the malarial pigment hemozoin directly limits the abundance and capacity of conventional type 1 dendritic cells to prime helper T cell responses.

Malaria Parasites Both Repress Host CXCL10 and Use It as a Cue for Growth Acceleration

[Nature Communications] Researchers showed a Pf ‘decision-sensing-system’ controlled by CXCL10 concentration. High CXCL10 expression prompted P. falciparum to initiate a survival strategy via growth acceleration.

Chemoprophylaxis Vaccination with a Plasmodium Liver Stage Autophagy Mutant Affords Enhanced and Long-Lasting Protection

[NPJ Vaccines] Scientists demonstrated that a liver stage-specific autophagy mutant of Plasmodium berghei, when used as a live vaccine under a chemoprophylaxis vaccination (CVac) regimen, provided superior long-lasting protection, in both inbred and outbred mice, as compared to WT-CVac.

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