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mammary cells

Intracellular CYTL1, a Novel Tumor Suppressor, Stabilizes NDUFV1 to Inhibit Metabolic Reprogramming in Breast Cancer

[Signal Transduction and Targeted Therapy] Researchers demonstrated that intracellular cytokine-like protein 1 (CYTL1) played a key role in preventing the robust glycolytic switching characteristics of breast cancer.

BRD4-Directed Super-enhancer Organization of Transcription Repression Programs Links to Chemotherapeutic Efficacy in Breast Cancer

[Proceedings of the National Academy of Sciences of the United States of America] Treatment of breast cancer cells with a small-molecule inhibitor of BRD4, JQ1, resulted in no immediate activation of the drug-resistant genes, but long-time treatment or destabilization of LSD1 by PELI1 decommissioned the BRD4/LSD1/NuRD complex.

ADRB3 Induces Mobilization and Inhibits Differentiation of Both Breast Cancer Cells and Myeloid-Derived Suppressor Cells

[Cell Death & Disease] ADRB3 promoted metastasis by inducing mobilization and inhibiting differentiation of both breast cancer cells and myeloid-derived suppressor cells.

DGKZ Promotes TGFβ Signaling Pathway and Metastasis in Triple-Negative Breast Cancer by Suppressing Lipid Raft-Dependent Endocytosis of TGFβR2

[Cell Death & Disease] Knockout of diacylglycerol kinase ζ (DGKZ) in TNBC cell lines were found to significantly inhibit metastatic behaviors in vitro and in vivo, whereas its overexpression increased the metastatic potential of cell lines.

Secretory Phospholipase sPLA2-IIAloss Impairs Tumorigenic and Metastatic Potential in Breast Cancer Cells

[Biochemical and Biophysical Research Communications] Scientists observed an increased level of EMT markers in CSC population. Overexpression of secretory phospholipase sPLA2-IIA was found in CSCs.

Ultrasound-induced Mechanical Stiffening in Acoustically-responsive Scaffolds Promotes Spatiotemporally-modulated Signaling in Triple Negative Breast Cancer

[Advanced Healthcare Materials] Researchers used a recently developed composite hydrogel composed of a fibrin matrix and phase-shift emulsion, termed an acoustically-responsive scaffold, to investigate effects of local mechanical properties on breast cancer cell signaling.

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