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mammary cells

Smoothened (SMO) Regulates Insulin-Like Growth Factor 1 Receptor (IGF1R) Levels and Protein Kinase B (AKT) Localization and Signaling

[Laboratory Investigation] Investigators provided evidence that elevated levels of human SMO showed a strong correlation with elevated levels of insulin-like growth factor 1 receptor and reduced survival in diffuse large B-cell lymphoma.

Nm23-H1 Activator Phenylbutenoid Dimer Exerts Cytotoxic Effects on Metastatic Breast Cancer Cells by Inducing Mitochondrial Dysfunction Only under Glucose Starvation

[Scientific Reports] The authors found that a small molecule phenylbutenoid dimer NMac1, a previously identified anti-metastatic agent, had novel anti-proliferative effect only under glucose starvation in metastatic breast cancer cells.

Excellent Effects and Possible Mechanisms of Action of a New Antibody–Drug Conjugate against EGFR-Positive Triple-Negative Breast Cancer

[Military Medical Research] Researchers evaluated the antitumor activities of LR004-VC-MMAE against epidermal growth factor receptor (EGFR)-positive TNBC and further studied its possible mechanism of antitumor action.

Cisplatin−Cyclooxygenase Inhibitor Conjugates, Free and Immobilised in Mesoporous Silica SBA-15, Prove Highly Potent against Triple-Negative MDA-MB-468 Breast Cancer Cell Line

[Dalton Transactions] For the development of anticancer drugs with higher activity and reduced toxicity, two approaches were combined: preparation of platinum complexes exhibiting higher stability compared to their platinum counterparts and loading them into mesoporous silica SBA-15.

Adipose Derived Mesenchymal Stem Cell Secretome Formulation as a Biotherapeutic to Inhibit Growth of Drug Resistant Triple Negative Breast Cancer

[Scientific Reports] Researchers developed a protocol for processing human adipose derived MSC secretome formulation of varying concentration. Its molecular composition was evaluated, and its effectiveness in vitro using breast cancer cell lines.

Microfluidic Organ-on-Chip System for Multi-Analyte Monitoring of Metabolites in 3D Cell Cultures

[Lab On A Chip] Investigators developed a microfluidic organ-on-chip platform for matrix-based, heterogeneous 3D cultures with fully integrated electrochemical chemo- and biosensor arrays for the energy metabolites oxygen, lactate, and glucose.

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