mammary cells

[Cell Death & Disease] Investigators showed that when Hsp70-binding protein 1 (HspBP1) was either knocked down or overexpressed in BRCA1-proficient breast cancer cells, there were profound changes in tumorigenesis, including anchorage-independent cell growth in vitro and in tumor formation in xenograft models.

[Aging] qRT-PCR was used to detect the expression of circular RNA_0006014 (hsa_circ_0006014) and related genes. MTT, colony formation and Transwell assays were used to explore the potential biological functions of hsa_circ_0006014 in breast cancer cells.

[Cell Death Discovery] Breast cancer-related microRNA (miRNA) and messenger RNA microarray data sets were retrieved for differential analyses. Subsequently, the expression patterns of miR-4731-5p, PAICS, and FAK in breast cancer tissues and cells were determined.

[Cell Death Discovery] Scientists investigated the effects of formin-like protein 2 (FMNL2) on breast cancer cell migration and invasion, and the underlying mechanisms involved.

[Scientific Reports] Researchers analyzed in vitro the effect of lysophosphatidic acid (LPA)18:1 and the LPA receptor 1 (LPAR1), LPAR3, and LPAR2 inhibitor Ki16425 on cellular functions of different human breast cancer cell lines and the human breast epithelial cell line, as well as Interleukin 8, Interleukin 6 and tumor necrosis factor-alpha cytokine secretion after LPA-incubation.

[npj Breast Cancer] Investigators showed that sulforaphane (SFN), including its two isomers of R-SFN and S-SFN, significantly inhibited transforming growth factor-β1-induced migration and invasion in breast cancer cells.