mammary cells

[Cellular Signalling] Researchers performed in silico analysis of microarray data from luminal, Her2+, and triple-negative breast cancer cell lines and identified 15 relatively unexplored epithelial-to-mesenchymal (EMT)-related differentially expressed genes along with the markedly high expression of EMT-transcription factor, SNAI1.

[Cell] Scientists showed that nuclear envelope ruptures induced DNA damage that promoted senescence in non-transformed cells and induced an invasive phenotype in human breast cancer cells.

[EMBO Journal] Investigators showed that the novel oncogene RASSF1C drove mesenchymal-to-amoeboid transition and stem cell attributes in breast cancer cells. Mechanistically, RASSF1C activated Rho/ROCK via SRC-mediated RhoGDI inhibition, resulting in generation of actomyosin contractility.

[npj Breast Cancer] From in vitro and in vivo studies, scientists concluded that Iminodibenzyl could reprogram COX-2 induced DGLA peroxidation to produce anti-cancer activity.

[Frontiers in Immunology] Investigators enriched ubiquitinated proteins (UPs) from epirubicin (EPB)-induced multi-drug-resistant cancer stem-like breast cancer cell line and tested the efficacy of α-Al2O3-UPs-4T1/EPB as therapeutic vaccine alone and in combination with the stimulator of interferon genes (STING) agonist in mice with drug-resistant and metastatic breast cancer.

[Cell Biochemistry and Function] The authors provide an overview of the key growth factors that trigger breast cancer angiogenesis.