mammary cells

[Scientific Reports] Researchers investigated the toxicity of different phosphate compounds to TNBCs, particularly, MDA-MB-231, and compared it to that of human monocytes, THP-1.

[Genomics] Investigators elucidated an important role of PIEZO1 in breast cancer and provided key clues for identifying PIEZO1 as a therapeutic target and prognostic biomarker in breast cancer.

[Molecular Cancer Research] Everolimus in combination with T-DM1 showed strong antitumor effects in HER2-positive breast cancer, both in vitro and in vivo.

[Life Science Alliance] The authors sought to alter transcriptional programs by enforcing expression of the catalytic domain of the methylcytosine dioxygenase TET2 in breast cancer cells.

[Molecular Oncology] Whether TGFβ promoted stemness and invasiveness simultaneously via epithelial-mesenchymal transition remained unclear. They established a breast cancer cell model expressing red fluorescent protein under the E-cadherin promoter.

[Cell Death & Differentiation] The authors illustrated that HIF-2α, but not HIF-1α, induced stemness in breast cancer cells under hypoxia through SOD2-mtROS-PDI/GRP78-UPRER pathway, linking mitochondrial metabolic state to endoplasmic reticulum response via mitochondrial reactive oxygen species level.