mammary cells

[npj Breast Cancer] Scientists investigated how IL-1B from tumour cells and the microenvironment interacted to affect primary tumour growth and bone metastasis through regulation of the immune system, and whether targeting IL-1 driven changes to the immune response improved standard of care therapy for breast cancer bone metastasis.

[Nature Communications] Investigators found that tumor endothelial marker 8 (TEM8) was abundantly expressed in triple-negative breast cancer and served as a marker for vasculogenic mimicry-forming breast tumor-initiating cells.

[Gene] Scientists evaluated the NANOG inhibition by siRNA and the increase of Let-7a by miRNA mimic in breast cancer cell lines and the effects of these changes on biologic aspects like apoptosis, stemness and invasion of these cells.

[Oncogene] Ligation of Dex and glucocorticoid receptor on tumor cells activated the PI3K signaling pathway and upregulated serum glucocorticoid-inducible kinase 1 expression, and then increased the expression of connective tissue growth factor through Nedd4l-Smad2.

[Scientific Reports] Scientists found that IL-1β-stimulated human umbilical cord-derived mesenchymal stem cells enhanced the expression of membrane-bound and soluble tumor necrosis factor-related apoptosis-inducing ligand.

[Cancer Research] Scientists used a network-based mathematical model to identify sensitivity regulators and drug combinations for the PI3Kα inhibitor alpelisib in ER+ PIK3CA mutant breast cancer. The combination of alpelisib and BH3 mimetics, e.g., MCL1 inhibitors, was experimentally validated in ER+ breast cancer cell lines.