mammary cells

[Cancers] Researchers demonstrated that long non-coding RNA prostate androgen regulated transcript 1 (PART1) was enriched in TNBCs. Knockdown of PART1 in TNBC cell lines and a patient-derived xenograft decreased cell proliferation, migration, tumor growth, and mammosphere formation potential.

[Cell Systems] Pooled fitness screens in two breast cancer cell lines revealed peptides, which selectively reduced cellular proliferation, implicating oncogenic protein domains important for cell fitness.

[Scientific Reports] Scientists studied the biological function of cytoplasmic maspin in breast cancer cell lines. Subcellular localization of maspin in MDA-MB-231 breast cancer cells was mainly detected in the cytoplasm, whereas in MCF10A mammary epithelial cells, maspin was present in both cytoplasm and nucleus.

[Cell Reports] Scientists established RBM39/MLL1 as a major contributor to the abnormal epigenetic landscape in breast cancer and laid the foundation for peptide-mediated cancer-specific therapy based on disruption of RBM39 epigenomic functions.

[Journal of Nanobiotechnology] Researchers prepared shell-core structure nanoparticles which inhibited tumor growth and angiogenesis in vitro and in MDA-MB-231 tumor-bearing mice via downregulating the sphingosine 1 phosphate receptor 1/phosphorylated signal transducer and activator of transcription 3/vascular endothelial growth factor A axis.

[Oncogenesis] Researchers investigated the relevance of the interactions between N-Myc and STAT Interactor protein (NMI) and various STATs to normal mammary development and cancer.