Tag results:

mammary stem cells

Procr Functions as a Signaling Receptor and Is Essential for the Maintenance and Self-Renewal of Mammary Stem Cells

[Cell Reports] By conditional knockout in mammary stem cells, investigators demonstrated that protein C receptor (Procr) is essential for mammary gland development and homeostasis.

An EMT–Primary Cilium–GLIS2 Signaling Axis Regulates Mammogenesis and Claudin-Low Breast Tumorigenesis

[Science Advances] Researchers showed that GLIS2 inactivation promoted mammary stem cell stemness, and GLIS2 is required for normal mammary gland development, while GLIS2 inactivation induced the proliferative and tumorigenic capacities of the mammary tumor–initiating cells of claudin-low breast cancers.

Asymmetric Cell Division of Mammary Stem Cells

[Cell Division] The authors discuss asymmetric cell division in breast/mammary stem cells and implications on further research, with focus on the role asymmetric cell division may play in breast cancer.

Regulation of a Progenitor Gene Program by SOX4 Is Essential for Mammary Tumor Proliferation

[Oncogene] Scientists investigated the loss of SOX4 in mammary tumor development utilizing organoids derived from a PyMT genetic mouse model of breast cancer.

Mammary Development and Breast Cancer: A Notch Perspective

[Journal of Mammary Gland Biology and Neoplasia] The authors discuss mechanisms by which Notch contributes to breast carcinoma pathology and suggest potentials for therapeutic targeting of Notch in breast cancer.

Repression of Endogenous Retroviruses Prevents Antiviral Immune Response and Is Required for Mammary Gland Development

[Cell Stem Cell] Investigators demonstrated that the loss of the lysine 9 of histone H3 methyltransferase G9a in the mammary epithelium resulted in de novo chromatin opening, aberrant formation of the mammary ductal tree, impaired stem cell potential, disrupted intraductal polarity, and loss of tissue function.

Popular