Two models have been proposed to explain the cell of origin of breast cancer and involve either the reprogramming of differentiated mammary cells or the dysregulation of mammary stem cells or progenitors. Both hypotheses are not exclusive and imply the accumulation of independent mutational events.
Investigators provide an overview of the latest research in the single-cell genomics of mammary gland development, which may help to understand the lineage commitment of mammary stem cells into luminal or basal epithelial cells that constitute the mammary gland.
When investigators analyzed only the genes that were differentially expressed in the stem cell enriched fraction, clusters of downregulated genes were related to proliferation, while among the upregulated expression, cluster of genes related to cell adhesion, migration and cytoskeleton organization were observed.
Martignani, E., Ala, U., Sheehy, P. A., Thomson, P. C., & Baratta, M. (2020). Whole transcriptome analysis of bovine mammary progenitor cells by P-Cadherin enrichment as a marker in the mammary cell hierarchy. Scientific Reports, 10(1), 14183. https://doi.org/10.1038/s41598-020-71179-4Cite