mast cells

[Molecular Medicine Reports] The authors determined whether Lycopus lucidus Turcz (LLT) could improve 2,4‑dinitrochlorobenzene‑induced dermatitis and to verify the inhibitory effect of LLT on the expression of chemokines and pro‑inflammatory cytokines in the HaCaT immortalized keratinocyte cell line.

[Immunologic Research] The authors explored the correlations between hyaluronic acid (HA) concentration versus mast cell proteases, or matrix metalloproteinase-2/9 and investigated the association of mast cell-specific proteases with disrupted synovial HA homeostasis in rheumatoid arthritis or collagen-induced arthritis rats.

[Stem Cell Research & Therapy] Researchers investigated whether coadministration with pimecrolimus, one of the topical calcineurin inhibitors, could influence the therapeutic potential of human umbilical cord blood MSCs in atopic dermatitis.

[AB Science SA] AB Science SA announced that it has received the first authorization to resume patient enrollment in the confirmatory Phase III study of masitinib in amyotrophic lateral sclerosis (ALS). Masitinib is a orally administered tyrosine kinase inhibitor that targets mast cells and macrophages, important cells for immunity, through inhibiting a limited number of kinases.

[American Journal of Physiology-Renal Physiology] As opposed to symptomatic uropathogenic E. coli-infected mice, treated mice showed reduced myosin light chain-2 phosphorylation, a marker of prostate smooth muscle contraction.

[Current Gastroenterology Reports] The authors present the current literature regarding the clinical presentation, diagnostic criteria, and management of eosinophilic gastritis/gastroenteritis.