mast cells

[Journal of Allergy and Clinical Immunology] Investigators developed a novel strategy for the rapid and efficient differentiation of mast cells from human iPSCs.

[Journal of Pathology] The authors characterized and assessed the prognostic potential of distinct immune cell infiltration patterns in the prostate tumor microenvironment.

[British Journal of Immunology] Investigators elucidated the function of short chain fatty acids on human basophils. Human basophils were purified from healthy donors by flow cytometric sorting.

[Nature Communications] Researchers found that extracellular vesicles released by neoplastic mast cells and present in the serum of patients with systemic mastocytosis blocked osteoblast differentiation and mineralization in culture, and when injected into mice diminished the expression of osteoblast markers, and trabecular bone volume and microarchitecture.

[Hoth Therapeutics, Inc.] Hoth Therapeutics, Inc. announced it intends to pursue development of its HT-KIT mRNA Frame Shifting Therapeutic for multiple orphan diseases, which are rare diseases that affect less than 200,000 people in the US. HT-KIT targets a shared cell signaling pathway that may have therapeutic potential for multiple rare cancers.

[International Journal of Molecular Sciences] The authors review both beneficial and detrimental functions of skin mast cells (MC), from skin barrier integrity via host defense mechanisms to MC-driven inflammatory skin disorders.