megakaryocytes

[Science Advances] Investigators developed a system for the production of platelet precursor cells, megakaryocytes, from PSCs. These cultures could be maintained for greater than 100 days, implying culture renewal by megakaryocyte progenitors.

[Cell Reports] The authors identified renal Klotho and inorganic phosphate as extrinsic factors that antagonistically regulate HSC maintenance in the bone marrow.

[Blood] Researchers comprehensively delineated human extramedullary hematopoietic stem and progenitor cell compartments comparing spleen, peripheral blood (PB) and mobilized PB (mPB) to bone marrow using single-cell RNA-seq and/or functional assays.

[International Journal of Hematology] Investigators encountered a case of human platelet antigen 15 (HPA-15) mismatched cord blood transplantation with a high HPA-15b antibody titer. Prolonged poor graft function and megakaryocyte aplasia with sustained high-titer HPA-15b antibodies were attenuated by rituximab therapy, and rapid recovery of hematopoiesis was achieved.

[Haematologica] The authors investigated whether the genes showing abnormal expression in FLI1-deficient platelets could be involved in platelet α-granule biogenesis by undertaking transcriptome analysis of control platelets and platelets harboring a DNA-binding variant of FLI1.

[Blood] Investigators suggested that serine-arginine rich splicing factor 3 (SRSF3) played a role in sorting cytoplasmic megakaryocyte RNAs into platelets and demonstratef how SRSF3-mediated RNA processing formed a central part of megakaryocyte gene regulation.