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megakaryocytes

Iron Deficiency as Promoter of Heavy Metals-Induced Acute Myeloid Leukemia

[Leukemia Research] Scientists discuss in detail the mechanisms involved in accumulation of cadmium in particular cell lines of the bone marrow and the consequent occurrence of acute myeloid leukemia.

CD62L Expression Level Determines the Cell Fate of Myeloid Progenitors

[Stem Cell Reports] Scientists identified CD62L as a marker to reveal the heterogeneity within progenitors. They confirmed that CD62L-negative common myeloid progenitors (CMPs) represent “bona fide” CMPs, and CD62L-high CMPs are mostly restricted to granulocyte-monocyte progenitors potentials in mice and humans.

Toward Platelet Transcriptomics in Cancer Diagnosis, Prognosis and Therapy

[British Journal of Cancer] The authors present a few actionable steps for basic, translational and clinical research communities in advancing the utility of the platelet transcriptome as a highly sensitive biomarker in cancer and collectively enable efforts toward clinical translation and patient benefit.

Therapeutic Use of Red Blood Cells and Platelets Derived from Human Cord Blood Stem Cells

[Stem Cells Translational Medicine] In this review, the gap between the many basic studies and limited clinical trials on stem cell-derived RBCs and platelets is summarized.

Myelodysplastic/Myeloproliferative Neoplasms-Unclassifiable with Isolated Isochromosome 17q Represents a Distinct Clinico-Biologic Subset: A Multi-Institutional Collaborative Study from the Bone Marrow Pathology Group

[Modern Pathology] Classification of myeloid neoplasms with isolated isochromosome i(17q) is controversial. Most cases fall within the WHO unclassifiable myelodysplastic/myeloproliferative neoplasms (MDS/MPN-U) category. Researchers undertook a multi-institutional retrospective study of 92 adult MDS/MPN-U cases from eight institutions.

CALR Frameshift Mutations in MPN Patient-Derived iPSCs Accelerate Maturation of Megakaryocytes

[Stem Cell Reports] Scientists generated patient-derived CALRins5- or CALRdel52-positive iPSCs to establish a myeloproliferative neoplasms disease model for molecular and mechanistic studies.

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