MEK1/2

[Cancer Research] Scientists generated pancreatic cancer cells resistant to Mek1/2 inhibition, which were also resistant to KRAS and Erk1/2 inhibitors.

[Biochemical Journal] Based on mRNA and protein expression profiling data, investigators found that αVβ1 integrin is the most abundant member of the αV integrin family in either quiescent or transforming growth factor β (TGF-β)1-activated primary human hepatic stellate cells.

[Nature Communications] Researchers use mass spectrometry to describe the molecular events triggered by inhibition of Mek1/2 and Gsk3 and inhibition of Cdk8/19 on ESCs.

[Journal of Hepatology] Tumor organoids and 2D cell lines derived from CCA lesions were addicted to FF signaling via Ras-Erk, regardless of FF identity or V565F mutation.

[Molecular Therapy-Methods & Clinical Development] Researchers established iPSCs from the peripheral blood of rhesus macaques (Rh-iPSCs) by combining the Yamanaka reprograming factors and two inhibitors and differentiated the cells into functional macrophages through hematopoietic progenitor cells.

[FEBS Journal] An in vitro model of paracrine interaction between primary cancer-associated fibroblasts and prostate cancer (Pca) cells was applied to investigate the molecular mechanism of SOX9 upregulation during Pca progression.