Tfap2b Specifies an Embryonic Melanocyte Stem Cell That Retains Adult Multifate Potential

Scientists found that Tfap2b and a select set of target genes specified an melanocyte stem cell population at the dorsal root ganglia in zebrafish.
[Cell Reports]
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Building and Maintaining the Skin

Investigators review diverse cellular interactions and highlight how far-reaching signals can be transmitted at the local level to enable skin stem cells to tailor their actions to suit the particular occasion and optimize fitness.
[Cold Spring Harbor Perspectives in Biology]
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AP-2alpha-Mediated Activation of E2F and EZH2 Drives Melanoma Metastasis

Researchers demonstrated that AP-2alpha facilitated melanoma metastasis through transcriptional activation of genes within the E2F pathway including EZH2.
[Cancer Research]
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Skin Pigmentation and its Control: From Ultraviolet Radiation to Stem Cells

Investigators discuss the pathways governing epithelial and follicular pigmentation, numerous areas of future research and potential points of intervention are highlighted.
[Experimental Dermatology]
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BMP Signaling: At the Gate Between Activated Melanocyte Stem Cells and Differentiation

The authors used single-cell RNA sequencing with comparative gene expression analysis to elucidate the transcriptional dynamics of melanocyte stem cells through quiescence, activation, and melanocyte maturation.
[Genes & Development]
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Hair Graying with Aging in Mice Carrying Oncogenic RET

Researchers found that the microscopic appearance of hair follicles without melanocyte stem cells and descendant melanocytes as well as macroscopic appearances of hair graying in RETā€transgenic mice carrying RET oncogene were in accordance with previously reported results for hair graying in humans.
[Aging Cell]
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