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melanocyte stem cells

Micro-Injury Induces Hair Regeneration and Vitiligo Repigmentation Through Wnt/β-Catenin Pathway

[Stem Cells and Development] Researchers discovered that proper micro-injury effectively induced hair regeneration by activating the hair follicle stem cell proliferation and migration downwards to the hair matrix, finally shifting the hair follicle stage from telogen into anagen.

Tfap2b Specifies an Embryonic Melanocyte Stem Cell That Retains Adult Multifate Potential

[Cell Reports] Scientists found that Tfap2b and a select set of target genes specified an melanocyte stem cell population at the dorsal root ganglia in zebrafish.

Building and Maintaining the Skin

[Cold Spring Harbor Perspectives in Biology] Investigators review diverse cellular interactions and highlight how far-reaching signals can be transmitted at the local level to enable skin stem cells to tailor their actions to suit the particular occasion and optimize fitness.

AP-2alpha-Mediated Activation of E2F and EZH2 Drives Melanoma Metastasis

[Cancer Research] Researchers demonstrated that AP-2alpha facilitated melanoma metastasis through transcriptional activation of genes within the E2F pathway including EZH2.

Skin Pigmentation and its Control: From Ultraviolet Radiation to Stem Cells

[Experimental Dermatology] Investigators discuss the pathways governing epithelial and follicular pigmentation, numerous areas of future research and potential points of intervention are highlighted.

BMP Signaling: At the Gate Between Activated Melanocyte Stem Cells and Differentiation

[Genes & Development] The authors used single-cell RNA sequencing with comparative gene expression analysis to elucidate the transcriptional dynamics of melanocyte stem cells through quiescence, activation, and melanocyte maturation.

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