melanocytes

[Communications Biology] The level of Dynlt3 is dependent on β-catenin activity, revealing a function of the Wnt/β-catenin signaling pathway during melanocyte and skin pigmentation, by coupling the transport, positioning and acidity of melanosomes required for their transfer.

[Cell Death & Disease] Researchers provide the first evidence that autophagy occured in melanocytes and fibroblasts from non-lesional skin of vitiligo patients, as a result of metabolic surveillance response.

[Journal of Experimental & Clinical Cancer Research] miR-106b-5p was enriched in melanoma cell-secreted exosomes and transferred to melanocytes. Exosomal miR-106b-5p promoted the epithelial-to-mesenchymal transition, migration, invasion and adhesion of melanocytes. Exosomal miR-106b-5p exerted its role by targeting erythropoietin-producing hepatocellular carcinoma receptor A4 (EphA4) to activate the ERK pathway.

[Nature Communications] Researchers introduced a computer-guided design tool that combines a computational framework for prioritizing more efficient combinations of instructive factors of cellular conversions, called IRENE, with a transposon-based genomic integration system for efficient delivery.

[Molecular Cancer Research] Investigators demonstrated that ERK2 drove BRAF-mutant melanoma gene expression and proliferation as a function of its higher expression compared to ERK1.

[Science Translational Medicine] Scientists report that patients with low melanoma neoantigen burdens who responded to ICI had tumors with higher expression of pigmentation-related genes.