melanoma

[Journal of Translational Medicine] High-throughput sequencing and bioinformatic analysis were employed to identify differentially expressed RNAs in platelet signatures of mice injected with a suboptimal number of melanoma cells compared with mice with macroscopic melanomas and negative controls.

[Cell Death & Disease] Scientists assessed the composition and production mechanisms, as well as the clinical significance and biological properties, of soluble CD74 in melanoma.

[Journal of Translational Medicine] Hepatic metastases was induced by intrasplenic injection of five different murine melanoma cell lines. The efficiencies of hepatic colonization, morphologic patterns, gene expression profiles and degree of vascularization were analyzed and Sorafenib was applied as anti-angiogenic treatment.

[Oncogene] The authors demonstrated that the N6-methyladenosine (m6A) reading protein YTHDF3 promoted the translation of the target transcript CTNNB1, contributing to ocular melanoma propagation and migration through m6A methylation.

[Cancer Gene Therapy] Researchers demonstrated that bone marrow MSC-derived extracellular vesicles carrying NEAT1 could promote the progression of melanoma by inducing M2 polarization of macrophages, and thus may be considered as a potential target for melanoma therapeutics.

[Scientific Reports] The authors constructed a pyroptosis-related gene signature in uveal melanoma patients. Patients from The Cancer Genome Atlas served as the training cohort, whereas patients from Gene Expression Omnibus served as the validation cohort.