melanoma

[Scientific Reports] The authors demonstrated that albendazole, an FDA-approved broad-spectrum antiparasitic agent, significantly inhibited the proliferation of melanoma cells in vitro and in vivo.

[Photochemistry and Photobiology] Investigators examine DNA damage in melanoma cells (B16-F10) with different melanin contents, subjected to 1O2 generation and used the photosensitizer Rose Bengal acetate and irradiation with visible light.

[Differentiation] The pluripotency of mESCs was significantly reduced through extracellular signal-regulated kinase 1/2 phosphorylation upon knockdown of Maged1, and through G1 cell cycle arrest during cell division, resulting in significantly reduced mESC proliferation.

[Scientific Reports] Researchers identified PPP6C, a serine/threonine phosphatase, as a key regulator of MITF in melanoma.

[Nature] Scientist sequenced the DNA of cutaneous and acral melanomas from a large cohort of human patients and found a specific enrichment for BRAF mutations in cutaneous melanoma and enrichment for CRKL amplifications in acral melanoma.

[Scientific Reports] The authors investigated the therapeutic potential of the AXL inhibitor BGB324 alone or in combination with the clinically relevant BRAF inhibitor vemurafenib.