Targeting Tumor-Associated Macrophages to Increase the Efficacy of Immune Checkpoint Inhibitors: A Glimpse into Novel Therapeutic Approaches for Metastatic Melanoma

The authors recapitulate the molecular mechanisms by which tumor-associated M2 macrophages (M2-TAMs) promote cancer immune evasion, with focus on the potential cross-talk between pharmacological interventions targeting M2-TAMs and immune checkpoint inhibitors for melanoma treatment.
[Cancers]
Ceci, C., Atzori, M. G., Lacal, P. M., & Graziani, G. (2020). Targeting Tumor-Associated Macrophages to Increase the Efficacy of Immune Checkpoint Inhibitors: A Glimpse into Novel Therapeutic Approaches for Metastatic Melanoma. Cancers, 12(11), 3401. https://doi.org/10.3390/cancers12113401 Cite
AbstractFull ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

A Framework of Major Tumor-Promoting Signal Transduction Pathways Implicated in Melanoma-Fibroblast Dialogue

Scientists analyze four major signaling pathways implicated in melanomagenesis, TGF-β, MAPK, Wnt/β-catenin and Hyppo signaling, from the complementary point of view of tumor cells and the microenvironment.
[Cancers]
Bellei, B., Migliano, E., & Picardo, M. (2020). A Framework of Major Tumor-Promoting Signal Transduction Pathways Implicated in Melanoma-Fibroblast Dialogue. Cancers, 12(11), 3400. https://doi.org/10.3390/cancers12113400 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Medicinal Potential of Mycelium and Fruiting Bodies of an Arboreal Mushroom Fomitopsis officinalis in Therapy of Lifestyle Diseases

Researchers aimed to investigate the antiproliferative activity of mycelium extracts and F. officinalis sporocarps against the the DU145 prostate cancer cell line, a melanoma cell line and a lung cancer cell line.
[Scientific Reports]
Fijałkowska, A., Muszyńska, B., Sułkowska-Ziaja, K., Kała, K., Pawlik, A., Stefaniuk, D., Matuszewska, A., Piska, K., Pękala, E., Kaczmarczyk, P., Piętka, J., & Jaszek, M. (2020). Medicinal potential of mycelium and fruiting bodies of an arboreal mushroom Fomitopsis officinalis in therapy of lifestyle diseases. Scientific Reports, 10(1), 20081. https://doi.org/10.1038/s41598-020-76899-1 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Mitochondrial Oxidative Phosphorylation in Cutaneous Melanoma

With the significant role of oxidative phosphorylation (OXPHOS) in metabolic plasticity and symbiosis, the authors outlines how mitochondrial transfer from mesenchymal stromal cells to melanoma tumor cells plays a key role in melanoma progression and is the mechanism by which melanoma cells regain OXPHOS capacity even in the presence of mitochondrial mutations.
[British Journal of Cancer]
Kumar, P. R., Moore, J. A., Bowles, K. M., Rushworth, S. A., & Moncrieff, M. D. (2020). Mitochondrial oxidative phosphorylation in cutaneous melanoma. British Journal of Cancer, 1–9. https://doi.org/10.1038/s41416-020-01159-y Cite
Abstract
Bookmark

No account yet? Register

0
Share

ST3GAL1 is a Target of the SOX2-GLI1 Transcriptional Complex and Promotes Melanoma Metastasis through AXL

Investigators report a mechanism regulated by the oncogenic SOX2-GLI1 transcriptional complex driving melanoma invasion through the induction of the sialyltransferase ST3GAL1. Using in vitro and in vivo studies, they demonstrated that ST3GAL1 drove melanoma metastasis.
[Nature Communications]
Pietrobono, S., Anichini, G., Sala, C., Manetti, F., Almada, L. L., Pepe, S., Carr, R. M., Paradise, B. D., Sarkaria, J. N., Davila, J. I., Tofani, L., Battisti, I., Arrigoni, G., Ying, L., Zhang, C., Li, H., Meves, A., Fernandez-Zapico, M. E., & Stecca, B. (2020). ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL. Nature Communications, 11(1), 5865. https://doi.org/10.1038/s41467-020-19575-2 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Flt3 Ligand Augments Immune Responses to Anti-DEC-205-NY-ESO-1 Vaccine through Expansion of Dendritic Cell Subsets

Researchers evaluated a regimen of Flt3L to increase DCs and other antigen-presenting cells, poly-ICLC and a vaccine comprising anti-DEC-205-NY-ESO-1, a fusion antibody targeting CD205, linked to NY-ESO-1.
[Nature Cancer]
Bhardwaj, N., Friedlander, P. A., Pavlick, A. C., Ernstoff, M. S., Gastman, B. R., Hanks, B. A., Curti, B. D., Albertini, M. R., Luke, J. J., Blazquez, A. B., Balan, S., Bedognetti, D., Beechem, J. M., Crocker, A. S., D’Amico, L., Danaher, P., Davis, T. A., Hawthorne, T., Hess, B. W., … Fling, S. P. (2020). Flt3 ligand augments immune responses to anti-DEC-205-NY-ESO-1 vaccine through expansion of dendritic cell subsets. Nature Cancer, 1–14. https://doi.org/10.1038/s43018-020-00143-y Cite
Abstract
Bookmark

No account yet? Register

0
Share

PharmaTher Expands Patent Portfolio with Filing of US Patent for Novel Use of Psilocybin to Treat Cancer

PharmaTher, Inc. has filed a provisional patent application with the US Patent and Trademark Office outlining the potential novel use of psilocybin to treat cancer, which was discovered by panaceAI™, their proprietary psychedelic drug repurposing artificial intelligence platform.
[PharmaTher, Inc. (GlobeNewswire, Inc.)]
Press Release
Bookmark

No account yet? Register

0
Share

Fra-2/AP-1 Regulates Melanoma Cell Metastasis by Downregulating Fam212b

Researchers showed that downregulation of the AP-1 transcription factor member Fra-2 in melanoma cells was associated with an aggressive melanoma phenotype in vitro and in vivo.
[Cell Death & Differentiation]
Chen, G.-L., Li, R., Chen, X.-X., Wang, J., Cao, S., Song, R., Zhao, M.-C., Li, L.-M., Hannemmann, N., Schett, G., Qian, C., & Bozec, A. (2020). Fra-2/AP-1 regulates melanoma cell metastasis by downregulating Fam212b. Cell Death & Differentiation, 1–15. https://doi.org/10.1038/s41418-020-00660-4 Cite
Full Article
Bookmark

No account yet? Register

0
Share

The Influence of Tumor Microenvironment on Immune Escape of Melanoma

The authors provides a comprehensive summary of the processes regulated by tumor-associated cells that promote the immune escape of melanoma cells.
[International Journal of Molecular Sciences]
Simiczyjew, A., Dratkiewicz, E., Mazurkiewicz, J., Ziętek, M., Matkowski, R., & Nowak, D. (2020). The Influence of Tumor Microenvironment on Immune Escape of Melanoma. International Journal of Molecular Sciences, 21(21), 8359. https://doi.org/10.3390/ijms21218359 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Single-Cell RNA Sequencing Unravels Heterogeneity of the Stromal Niche in Cutaneous Melanoma Heterogeneous Spheroids

Scientists focused on the analysis of microenvironmental factors introduced in melanoma heterogeneous spheroids by different dermal fibroblasts.
[Cancers]
Novotný, J., Strnadová, K., Dvořánková, B., Kocourková, Š., Jakša, R., Dundr, P., Pačes, V., Smetana Jr, K., Kolář, M., & Lacina, L. (2020). Single-Cell RNA Sequencing Unravels Heterogeneity of the Stromal Niche in Cutaneous Melanoma Heterogeneous Spheroids. Cancers, 12(11), 3324. https://doi.org/10.3390/cancers12113324 Cite
AbstractGraphical Abstract
Bookmark

No account yet? Register

0
Share

PLK1 and NOTCH Positively Correlate in Melanoma and their Combined Inhibition Results in Synergistic Modulations of Key Melanoma Pathways

Employing an in-house human melanoma tissue microarray containing multiple cases of melanomas and benign nevi, coupled with high-throughput, multispectral quantitative fluorescence imaging analysis, researchers found a positive correlation between PLK1 and NOTCH1 in melanoma.
[Molecular Cancer Therapeutics]
Su, S., Chhabra, G., Ndiaye, M. A., Singh, C. K., Ye, T., Huang, W., Dewey, C. N., Setaluri, V., & Ahmad, N. (2020). PLK1 and NOTCH Positively Correlate in Melanoma and their Combined Inhibition Results in Synergistic Modulations of Key Melanoma Pathways. Molecular Cancer Therapeutics. https://doi.org/10.1158/1535-7163.MCT-20-0654 Cite
Abstract
Bookmark

No account yet? Register

0
Share
Share