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melanoma

BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment

[Cancer Research] Emerging evidence indicates B cell activating factor (BAFF) to be an important cytokine for anti-tumor immunity. The authors generated a BAFF-overexpressing B16.F10 melanoma cell model and found that BAFF-expressing tumors grew more slowly in vivo than control tumors.

ADT-OH Inhibits Malignant Melanoma Metastasis in Mice via Suppressing CSE/CBS and FAK/Paxillin Signaling Pathway

[Acta Pharmacologica Sinica] The authors demonstrated that 5-(4-hydroxyphenyl)−3H-1,2-dithiocyclopentene-3-thione (ADT-OH) inhibited the EMT process in melanoma cells by suppressing the CSE/CBS and FAK signaling pathways, thereby exerting its antimetastatic activity.

MMP-9 Drives the Melanomagenic Transcription Program through Histone H3 Tail Proteolysis

[Oncogene] Investigators reported that matrix metalloproteinase 9 (MMP-9) localized to the nucleus of melanoma cells and potentiated gene expression by proteolytically clipping the histone H3 N-terminal tail.

Isoform Specific Anti-TGFβ Therapy Enhances Antitumor Efficacy in Mouse Models of Cancer

[Communications Biology] Using B16 mouse melanoma and CT26 colon carcinoma as models of stroma-poor tumors, researchers demonstrated that myeloid/dendritic cells were the main sources of TGFβ1 and TGFβ3.

Chemogenetic Modulation of Sensory Neurons Reveals Their Regulating Role in Melanoma Progression

[Acta Neuropathologica Communications] Whether sensory neuronal activity is important for tumor progression remains unknown. Researchers suggested that sensory innervations regulate melanoma progression, indicating that manipulation of sensory neurons’ activity may provide a valuable tool to improve melanoma patients’ outcomes.

Autotaxin Impedes Anti-Tumor Immunity by Suppressing Chemotaxis and Tumor Infiltration of CD8+ T Cells

[Cell Reports] Investigators showed that autotaxin (ATC) secreted by melanoma cells was chemorepulsive for tumor-infiltrating lymphocytes and circulating CD8+ T cells ex vivo, with autotaxin functioning as an LPA-producing chaperone.

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