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melanoma

Impact of Intracellular Innate Immune Receptors on Immunometabolism

[Cellular & Molecular Immunology] Toll-like receptors, cytokine receptors, and T and B cell receptors have been shown to activate multiple downstream metabolic pathways. However, how intracellular innate immune sensors/receptors intersect with metabolic pathways is less well understood.

REDD1 Is a Determinant of Low-Dose Metronomic Doxorubicin-Elicited Endothelial Cell Dysfunction through Downregulation of VEGFR-2/3 Expression

[Experimental and Molecular Medicine] Researchers examined the functional role of regulated in development and DNA damage responses 1 (REDD1), an inhibitor of mammalian target of rapamycin complex 1, in low-dose metronomic chemotherapy-mediated endothelial cell dysfunction.

Development of ICT01, a First-in-Class, Anti-BTN3A Antibody for Activating Vγ9Vδ2 T Cell–Mediated Antitumor Immune Response

[Science Translational Medicine] The authors described the development of a humanized monoclonal antibody, ICT01, with subnanomolar affinity for the three isoforms of BTN3A.

Fibrinolytic Nanocages Dissolve Clots in the Tumor Microenvironment, Improving the Distribution and Therapeutic Efficacy of Anticancer Drugs

[Experimental and Molecular Medicine] Investigators used thrombolytic nanocages with multivalent clot-targeting peptides and fibrin degradation enzymes, such as microplasmin, to dissolve fibrin in the tumor microenvironment and named them fibrinolytic nanocages.

Molecular Characterization of Biphenotypic Epithelioid and Plexiform Melanoma with Deep Penetrating Nevus (DPN)-Like Features

[Pigment Cell & Melanoma Research] Scientists investigated a case of melanoma that displayed a dual phenotype: a DPN-like/plexiform portion in conjunction with a conventional epithelioid morphology.

Therapeutic Melanoma Inhibition by Local Micelle-Mediated Cyclic Nucleotide Repression

[Nature Communications] Researchers demonstrated that single-cell sequencing of melanoma-infiltrating immune cells showed that adenylate cyclase inhibitor micelles reduced the number of anti-inflammatory myeloid cells and checkpoint receptor expression on T cells.

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